Published date: Sep 11 2017

Journal Title: KnE Life Sciences

Issue title: International Conference on Natural Resources and Life Sciences (NRLS-2016)

Pages: 51-62

DOI: 10.18502/kls.v3i5.978

Bimo Budi Santosoyanakaresta@gmail.comDepartment of Chemistry, Faculty Mathematics and Natural Sciences, University of Papua, Jl. Gunung Salju Amban, Manokwari 98314, Indonesia

Hidelisa Padua Hernandez

Evelyn B Rodriguez

Ida Farida Dalmacio

Antimicrobial-guided fractionation and isolation of the bioactive compounds from the stem bark of Drimys arfakensis Gibbs. were carried out. Two antibacterial compounds were isolated. The sructures of the antibacterial compounds were elucidated by spectroscopic methods such as ¹H NMR, ¹³C NMR, 2-D NMR, ESI-MS and EI-MS. Based on the spectroscopic data, the two antibacterial compounds were velutin, 1 and  4-(hydroxyl(oxiran-2-yl)methyl)-2-methoxyphenol, 2. Compound 1 exhibited low activity against methicillin-resistant Staphylococcus aureus (MRSA) (B-1823) with MIC value of 250 µg · mL^–1, while compound 2 possesses strong activity against S. aureus (MRSA) (B-1823) with MIC value of 15.60 µg · mL^–1.No activity of both compounds against Escherichia coli (B-1634) and Candida albicans (B-2219) was observed.

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