Published date: Apr 05 2021

Journal Title: KnE Life Sciences

Issue title: DonAgro: International Research Conference on Challenges and Advances in Farming, Food Manufacturing, Agricultural Research and Education

Pages: 622–631

DOI: 10.18502/kls.v0i0.8998

Vladimir Titov vtitov43@yandex.ruFederal Scientific Center All-Russian Research and Technological Poultry Institute of the Russian Academy of Sciences, Moscow Region, Sergiev Posad, Russia; Moscow State Academy of Veterinary Medicine and Biotechnology – MVA named after K.I. Skryabin, Moscow, Russia

Anna DolgorukovaFederal Scientific Center All-Russian Research and Technological Poultry Institute of the Russian Academy of Sciences, Moscow Region, Sergiev Posad, Russia

Lyudmila KhasanovaFederal Scientific Center All-Russian Research and Technological Poultry Institute of the Russian Academy of Sciences, Moscow Region, Sergiev Posad, Russia

Ivan KochishMoscow State Academy of Veterinary Medicine and Biotechnology – MVA named after K.I. Skryabin, Moscow, Russia

Maxim KorenyugaMoscow State Academy of Veterinary Medicine and Biotechnology – MVA named after K.I. Skryabin, Moscow, Russia

Nitric oxide (NO) is intensively synthesized in the embryo of birds. There is evidence that NO mediates myogenesis at the embryonic stage. In this regard, it might be possible to control muscle development and meat productivity by modulating NO synthesis. Using high-precision and a highly sensitive enzymatic sensor, the authors found that it is not the rate of synthesis that correlates with meat productivity, but the rate of NO oxidation to nitrate, which occurs in the tissues of the embryo. In broilers, it is several orders of magnitude higher than in layers. This indicator is solely due to the characteristics of embryonic tissues and is allelically determined. In-ovo arginine supplementation, a source of NO, did not lead to a significant increase in its synthesis and oxidation, but occasionally increased live weight gain, which was likely associated with a deficiency of free arginine and was not directly related to the effect of nitric oxide. Exogenous NO donors were oxidized with the same intensity as endogenous donors. These compounds did not have a significant effect on growth rate. Also, a reduction of 50% in the rate of NO synthesis under the action of a NO synthase inhibitor did not affect this parameter. Thus, regulation of poultry meat productivity is possible by modulating gene expression related to embryonic NO oxidation and ensuring an optimal amino acid and energy equilibrium, rather than by promoting embryonic NO synthesis.

Keywords: Nitric oxide (NO), NO donor compounds, nitrate, arginine, live weight

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