Published date: Apr 05 2021

Journal Title: KnE Life Sciences

Issue title: DonAgro: International Research Conference on Challenges and Advances in Farming, Food Manufacturing, Agricultural Research and Education

Pages: 533–541

DOI: 10.18502/kls.v0i0.8987

Svetlana Platonova s.vasileva89@yandex.ruFederal State Budget Scientific Institution “Federal Scientific Center VIEV”, Moscow, Russia

Daria KorovinaFederal State Budget Scientific Institution “Federal Scientific Center VIEV”, Moscow, Russia

Ekaterina ViktorovaFederal State Budget Scientific Institution “Federal Scientific Center VIEV”, Moscow, Russia

Irina SavchenkovaFederal State Budget Scientific Institution “Federal Scientific Center VIEV”, Moscow, Russia

The application of animal mesenchymal stem cells has been actively studied in veterinary medicine over the past decade. In horses, the use of stem cells is mainly aimed at the treatment and maintenance of the musculoskeletal system. This review summarizes the currently published data on the therapeutic use of mesenchymal stem cells in equine tendon injuries. Tendon lesions are the most common cause of horse limp. It has been demonstrated that the use of mesenchymal stem cells compared with traditional methods of treatment can significantly reduce the re-injury. Currently, there are a large number of stem cell application protocol versions. Many researchers have obtained positive clinical results in using a combination of mesenchymal stem cells and platelet-rich blood plasma. Studies have demonstrated the safety of using allogeneic mesenchymal stem cells as an alternative to autologous. This review shows that the application of mesenchymal stem cells for horse tendon regeneration is a perspective area in veterinary medicine.

[1] Bavin, E. P., et al. (2015). Equine Induced Pluripotent Stem Cells Have a Reduced Tendon Differentiation Capacity Compared to Embryonic Stem Cells. Frontiers in Veterinary Science, vol. 2, p. 55.

[2] Shojaee, A. and Parham, A. (2019). Strategies of Tenogenic Differentiation of Equine Stem Cells for Tendon Repair: Current Status and Challenges. Stem Cell Research and Therapy, vol. 10, issue 1, p. 181.

[3] Dyson, S. J. (2004). Medical Management of Superficial Digital Flexor Tendonitis: A Comparative Study in 219 Horses (1992–2000). Equine Veterinary Journal, vol. 36, issue 5, pp. 415–419.

[4] Savchenkova, I. P., et al. (2010). Methodical Instructions on the Selection of Multipotent Mesenchymal Stem Cells from the Tissues of Adult Mammals, the study of their properties and signs. Publishing House Sputnik+, p. 22.

[5] Smith, R. K., et al. (2003). Isolation and Implantation of Autologous Equine Mesenchymal Stem Cells from Bone Marrow into the Superficial Digital Flexor Tendon as a Potential Novel Treatment. Equine Veterinary Journal, vol. 35, issue 1, pp. 99–102.

[6] Smith, R. K. (2008). Mesenchymal Stem Cell Therapy for Equine Tendinopathy. Disability and Rehabilitation, vol. 30, issue 20-22, pp. 1752–1758.

[7] Godwin, E. E., et al. (2012). Implantation of Bone Marrow-Derived Mesenchymal Stem Cells Demonstrates Improved Outcome in Horses with Overstrain Injury of the Superficial Digital Flexor Tendon. Equine Veterinary Journal, vol. 44, issue 1, pp. 25–32.

[8] Nixon, A. J., et al. (2008). Effect of Adipose-Derived Nucleated Cell Fractions on Tendon Repair in Horses with Collagenase-Induced Tendinitis. American Journal of Veterinary Research, vol. 69, issue 7, pp. 928–937.

[9] Carvalho, A. M., et al. (2011). Use of Adipose Tissue-Derived Mesenchymal Stem Cells for Experimental Tendinitis Therapy in Equines. Journal of Equine Veterinary Science, vol. 31, issue 1, pp. 26–34.

[10] Vasileva, S. A. (2019). Characterization of Multipotent Mesenchymal Stem Cells Isolated from Equine Adipose Tissue and Umbilical Cord Blood. Actual Biotechnology, vol. 3, issue 30, pp. 298–300.

[11] Beerts, C., et al. (2017). Tenogenically Induced Allogeneic Peripheral Blood Mesenchymal Stem Cells in Allogeneic Platelet-Rich Plasma: 2-Year Follow-Up after Tendon or Ligament Treatment in Horses. Frontiers in Veterinary Science, vol. 26, issue 4, p. 158.

[12] Longhini, A. L. F., et al. (2019). Peripheral Blood-Derived Mesenchymal Stem Cells Demonstrate Immunomodulatory Potential for Therapeutic Use in Horses. PLoS One, vol. 14, issue 3, p. e0212642.

[13] Prado, A. A., et al. (2015). Characterization of Mesenchymal Stem Cells Derived from the Equine Synovial Fluid and Membrane. BMC Veterinary Research, vol. 11, p. 281.

[14] Koch, T. G., et al. (2007). Isolation of Mesenchymal Stem Cells from Equine Umbilical Cord Blood. BMC Biotechnology, vol. 7, p. 26.

[15] Kang, J. G., et al. (2013). Characterization and Clinical Application of Mesenchymal Stem Cells from Equine Umbilical Cord Blood. Journal of Veterinary Science, vol. 14, issue 3, pp. 367–371.