Published date: Apr 05 2021

Journal Title: KnE Life Sciences

Issue title: DonAgro: International Research Conference on Challenges and Advances in Farming, Food Manufacturing, Agricultural Research and Education

Pages: 240–246

DOI: 10.18502/kls.v0i0.8953

Pavel Khristianovsky Paor1953@bk.ruFederal Research Centre of Biological Systems and Agrotechnologies, RAS, Orenburg, Russia

Vladislav BelimenkoFederal Scientific VIEV, RAS, Moscow, Russia

Babesiosis (piroplasmosis) is a transmissible parasitic disease, accompanied by fever, anemia, yellowness of the mucous membranes, hemoglobinuria, lost productivity and performance, and with untimely treatment – death of livestock. Therapy to treat livestock babesiosis involves, first of all, the use of anti-babesial drugs. This study aimed the examine the effectiveness of using a reduced diminazene aceturate (DA) dosage against babesiosis in livestock. However, the use of these drugs can cause side effects. The study recommends the use of DA-based drugs against equine babesiosis at a dose of 2.6 mg/kg bodyweight for an active ingredient (AI). With volumetric dosing it is 0.038 cm3 of a 7 % solution per kg bodyweight, rather than 0.05 cm3 per kg bodyweight, as indicated in the instructions. The use of a reduced dose of Batrizin (2.5 and 3.0 mg/kg AI) and Fa.Try.Banil. (2.5 mg/kg AI) to treat experimental babesiosis in dogs had a satisfactory anti-babesial effect in the absence of intoxication.

Keywords: diminazene aceturate, babesiosis, parasitic disease

[1] Koster, L., Lobetti, R. and Kelly, P. (2015). Canine Babesiosis: A Perspective on Clinical Complications, Biomarkers, and Treatment. Veterinary Medicine: Research. and Reports, vol. 6. pp. 119–28.

[2] Glazunov, Y. V. and Glazunova, L. A. (2018). Phenology of Pasture Ticks in the Trans-Urals. Indian Veterinary. Journal, vol. 95, issue 1, pp. 19–22.

[3] Belimenko, V. V. (2016). Protozoan Diseases in Pets. Moscow: Infra-M.

[4] Belimenko, V. V., Novosad, E. V. and Gulyukin, A. M. (2017). The Economic Damage from Piroplasmidoses in Farm Animals in Russia. Veterinaria. Kubani, vol. 2, pp. 6–7.

[5] Stolbova, O. A., Glazunov, Y. V. and Skosyrskikh, L. N. (2018). Ticks — Parasites of Dogs in Northern Trans-Urals. Indo American Journal of Pharmaceutical Sciences, vol. 5, issue 3, pp. 1675–82.

[6] Belimenko, V. V., et al. (2019). Effect of Enrofloxacin for Treatment of Bovine Anaplasmosis and Canine Babesiosis. IOP Conference Series: Earth and Environmental Science. vol. 315. issue 4. art. 042016

[7] Piana, G. P. and Galli-Valerio, B. (1895). Su Di Un Infezione Del Cane Con Parassiti Endoglobulari Nel Sangue. Moderno Zooiatro, vol. 6, pp. 163–9.

[8] Belimenko, V. V. (2013). Canine Babesiosis in the Russian Federation. Journal Small Animal Practice, vol. 4, issue 6, pp. 43–6.

[9] Vial, H. J. and Gorenflot, A. (2006). Chemotherapy against Babesiosis. Veterenarian Parasitology, vol. 138, issue 1-2, pp. 147–60.