KnE Life Sciences

ISSN: 2413-0877

The latest conference proceedings on life sciences, medicine and pharmacology.

Clinical-laboratory Manifestations of Myocarditis in Dogs

Published date: Nov 25 2019

Journal Title: KnE Life Sciences

Issue title: International Scientific and Practical Conference “AgroSMART – Smart Solutions for Agriculture”

Pages: 820–832

DOI: 10.18502/kls.v4i14.5679

Authors:
Abstract:

The leading clinical signs of myocarditis in dogs were the sudden development of signs of disease, refusal to eat, dyspnea at rest, rapid fatigue. At the diagnostic stage, the position of animals forced, lying, increased breathing speed up to 60-72 movements per minute, pale visible mucous membranes and conjunctiva, weak filling of pulse, rapid filling of capillaries, high blood pressure, increase in the number of leukocytes up to 25–27×109/l, SRS up to 15,4–17,4 mg/l, troponin up to 3,85–4,2 ng/ml. Electrocardiographic study established sinus or ectopic rhythm, heart rate 133– 198 oz/min, conductivity disturbance and deceleration. ECHOKG showed moderate expansion of the left ventricle, moderate expansion of the left atrium. Sealing of the mitral valve leaves, regurgitation on the mitral valve of the first degree. Left ventricular myocardium is inhomogeneous, wall echogenicity is increased. Fraction of contractility 16–18 %. After establishment of a dietary regime and correction of conditions of the maintenance, to dogs strictly with a twelve-hour interval twice a day are appointed vedmedin (0,25 mg/kg), sotalol (1,5 mg/kg), sinulox (20 mg/kg), mexidol-vet (1 table), verospheron (1 mg/kg). As a result of four-week monitoring of patients’ condition positive results were noted: lack of dyspnea, normalization of pulse rate and blood pressure, reduction of capillary filling rate up to 1 second, leukocyte concentration up to 12,6–15,7 ×109/l, SRS up to 1,3–1,4 mg/l, troponin up to 0,09–0,17 ng/ml. The electrocardiographic study showed a decrease in the height of teeth R and P, increase in the intervals P-Q and Q-T. The sinus rhythm is irregular. Echokg showed expansion of the left ventricle, moderate expansion of the left atrium. Sealing of mitral valve leaves, regurgitation on mitral valve of the first degree. Left ventricular myocardium is less heterogeneous, wall echogenicity is increased. Fraction of contractility 23–24 %. It is difficult to predict the outcome of the disease at this stage, as the age of dogs is 7–12 years, and in many respects the quality of life will be provided by their owners.

References:

[1] Blagova, O.V. (2014). Not accessible. Modern myocarditis masks (from clinical syndromes to diagnosis). Russian Cardiology Journal, no. 5(100), pp. 13–22. Moscow: FIRMA SILICEIA LLC.

[2] Dog and cat diseases. Complex diagnostics and therapy. (2013). Under edition of Stekolnikova, A.A., Staroverova, S.V. 4rd ed., op. and extra. St. Petersburg: SpetsLit, 925 p.

[3] Vasilieva, V.A., Prokhorova, E.V., Kulikova, N.N., Nebaikina, L.A. (2006). Treatment of myocarditis in dogs. Successes of modern science, no. 1, pp. 48–49. Belgorod: Successes of modern science.

[4] Gerke, V.S. (2013). Fundamentals of cardiological examination of dogs. Vetpharma, no. 4, pp. 40–46. Moscow: Medical Information Agency ``MEDFORUM''.

[5] Gilyarovsky, S.R. (2008). Myocarditis: modern approaches to diagnosis and treatment. Moscow: Media Sphere, 324 p.

[6] Golokhvast, K.S., Panichev, A.M., Automonov, E.G. (2010). Ecological aspects of interaction between living organisms and mineral factors of the environment. Proceedings of the II International Symposium ``Ecological problems of animals and humans''. (Ministry of Agriculture of the Russian Federation; Novosibirsk State Agrarian University; Research Institute of Animal Husbandry; Biotechnological Institute, 29–30 October 2009). Novosibirsk, pp. 25–27.

[7] Donnik, I.M., Shkuratova, I.A. (2011). Environment and animal health. Veterinary of Kuban, Krasnodar: Krasnodar Regional Public Veterinary Organization, no. 2, pp. 12–13.

[8] Julikova, O.A. (2016). Monitoring of cardiovascular diseases among cats and dogs in Blagoveshchensk, Amur region. Far Eastern Agrarian Bulletin, Blagoveshchensk: FSBEI ``Far Eastern State Agrarian University'', no. 2(38), pp. 49–56.

[9] Ivanova, S.V., Titov, V.A., Mitrofanova, L.B., Moiseeva, O.M. (2018). Analysis of the causes of late diagnosis of myocarditis. Translational Medicine, no. 5(2), pp. 5–14. St. Petersburg: National Medical Research Center named after V.A. Almazov.

[10] Isakov, L.K., Tarasov, N.I., Sinkova, M.N., Vakhovskaya, I.M. (2017). Clinical case of a favorable outcome of undiagnosed myocarditis. Fundamental and clinical medicine, vol. 2, pp. 83–91. Kemerovo: FSBEI HEI "Kemerovo State Medical University.

[11] Kozlovskaya, N.G. (2013). Breed predisposition of dogs and cats to cardiological diseases. RHD. MWA, no. 6, pp. 32–35. Moscow: Logos Press.

[12] Koroleva, A.A., Zhuravkov, Y.L. Modern approaches to diagnosis and treatment of myocarditis. Retrieved from: file:///C:/Users/%D0%9B%D1%D1%E%D0%B4%D0% D0%BC%D0%B8%D0%B%D0%B0/Downloads/2013011410411110.pdf (assessed on 07.02.2019).

[13] Martin, V.S., Corcorin, B.M. (2004). Cardiorespiratory diseases of dogs and cats. Moscow: Aquarium-Print, 496 p.

[14] Martynov, A.N., Turkov, V.G., Kletikova, L.V., Zybina, T.N. (2016). Diabetes mellitus in cats associated with metabolic syndrome. Successes of modern science, vol. 3, no. 2, pp. 6–11. Belgorod.

[15] Mitkovskaya, N.P., Grigorenko, E.A., Danilova, L.I. (2008). Heart and metabolic risk. Minsk: Belarus. Science, 277 p.

[16] Niemand, H.G., Souter, P.F. (2001). Dog diseases. Practical guidelines for veterinarians (organization of a veterinary clinic, examination, diagnosis of diseases, treatment), 2rd ed. Moscow: Aquarium LTD, 816 p.

[17] Paleyev, N.R., Paleyev, F.N. (2009). Non-coronarogenic myocardial diseases and their classification. Russian Cardiological Journal, no. 3(77), pp. 5–9. Moscow: FIRMA SILITSEA LLC.

[18] Roberto, A. Santilli. (2017). Etiology of myocarditis. Therapeutic strategies. What we can use in clinical practice and how to interpret myocardial biopsy. Vetpharma, no. 3. Moscow: Agency for Medical Information MEDFORUM.

[19] Rogachev, A.S. (2015). Blood diagnostic examination for the content of cardiac troponins. RHV. MWA, no. 1, pp. 32–33. Moscow: Logos Press.

[20] Rudenko, A.A. Distribution of cardiomyopathies and other cardiovascular diseases in dogs. Retrieved from: http://xn--80abelqjzx5d.su/rasprostranenie-kardiomiopatiji- drugih-boleznej-serdechno-sosudistoj-sistemy-u-sobak.html (accessed on 08.02.2019).

[21] Swanton, H., Harband, R.K .(2001). Diagnostics and treatment of myocarditis. Retrieved from: https://www.lvrach.ru/2001/07/4528851/ (accessed on 04.02.2019).

[22] Skvortsov, V.V., Tumarenko, A.V., Odintsov, V.V., Orlov, O.V., Skvortsova, E.M. (2009). Russian Cardiology Journal, no. 1(75), pp. 87–96. Moscow: FIRMA SILITSEA LLC.

[23] Modern course of veterinary medicine by Kirk. (2005). Moscow: Aquarium-Print, 1376 p. [24] Starchenkov, S.V. (2001). Dog and cat diseases. St. Petersburg: Lan, 560 p. [25] Storozhkov, G.I., Gorbachenkov, A.A. (2008). Guidance on cardiology, vol. 1. Moscow: Geotar-Media, 682 p.

[26] Suther, P., Kon, B. (2011) Dog diseases, 10rd ed., full reworking and rass. Moscow: Aquarium-Print, 1384 p.

[27] Khrushcheva, V.P., Shumakov, V.V., Martynov, A.N., Kletikova, L.V. (2017). Analysis of the incidence of cardiovascular pathology in small domestic animals in the period from 2012 to 2015. Agrarian Bulletin of the Upper Volga region, FGBOU ETO Ivanovskaya SSKHA, no. 3, pp. 25–31.

[28] Church, W.M., Sisson, D.D., Oyama, M.A., Zachary, J.F. (2007). Third degree atrioventricular block and sudden death secondary to acute myocarditis in a dog. J. Vet. Cardiol., no. 9. pp. 53–57.

[29] Janus, I., Noszczyk-Nowak, A., Nowak, M. et al. (2018). Biocarditis in Dogs: Etiology, Clinical Symptoms and Histopathological Signs (Overview of 11 Clinical Cases: 2007–2013). Modern Veterinary Medicine. Cardiology (Special Iss.), pp. 34–42. Moscow: Zooinform Research Center LLC.

[30] Ketal, G.D. (2005). Reduction of infarct size and postischemic inflammation from ATL-146e, a highly selective adenosine A2A receptor agonist, in reperfused canine myocardium. Am J. Physiol Heart Circ Physiol, vol. 288(4), pp. H1851–H1858.

[31] Kaneshige, T., Machida, N., Nakao, S., Doiguchi, O., Katsuda, S., Yamane, Y. (2007). Complete atrioventricular block associated with lymphocytic myocarditis of the atrioventricular node in two young adult dogs. J. Comp. Path., vol. 137, pp. 146–150.

[32] Mason, J.W., OʼConnell, J.B., Nerskowitz, A. et al. (1995). A clinical trial of immunnosupressive therapy for myocarditis. N. Engl. J. Med. vol. 333, pp. 269–275.

[33] Silvestrini, P. et al. (2012). Serum cardiac troponin I concentrations in dogs with leishmaniasis: correlation with age and clinicopathologic abnormalities. Vet Clin Pathol Sep 12.

[34] Woolley, R., Blundell, R., Else, R., Corcoran, B., Devine, C., French, A. (2007). Atrial myocarditis as a cause of sinus arrest in a dog. J. Small. Anim. Pract., no. 48, pp. 455–457.

Download
HTML
Cite
Share
statistics

356 Abstract Views

294 PDF Downloads