Published date: Mar 07 2019

Journal Title: KnE Life Sciences

Issue title: The 2nd International Meeting of Public Health 2016 (IMOPH) – Part II

Pages: 39–50

DOI: 10.18502/kls.v4i10.3766

D Prabaningrumprabaningrum.dyah@hotmail.com

Dioxins and dioxin-like compounds are widely spread in the environment and listed as POPs contaminants which in a certain level of exposure, it associated with neurodevelopmental defects in childhood. Studies in animals resulted in the association between dioxins and dioxin-like exposure and neuro-developmental
abnormalities. However, studies in human result varied association between exposure and neurodevelopment outcomes. This review was to observe variables in several publications about dioxins and dioxin-like exposure and its effects to neurodevelopment in children. Reviewed variables are dioxins and dioxin-like concentration in mother, breastfeeding duration, and neuro-developmental test scores. Six reviewed studies evaluated dioxins and dioxins like exposure and its effects in neuro-development in children. Reviewed studies were conducted in the highly contaminated area and area with no particular high exposure to dioxins or dioxin-like. This review resulted in the exposure through prenatal and perinatal, or breastfeeding was not clearly explaining the
effects on neurodevelopment in children. A subtle difference of neuro-developmental defects may not be able to be assessed only by neuro-developmental assessment tools. This review suggested evaluating background level of dioxins and dioxin-like in the environment, dietary intake in mother, examining specific congeners and its effects to cognitive and motor development aspects, and consider other methods to examine mild changes in children neurodevelopment such as neuropsychological measurement.

Keywords: Dioxin; Dioxin-like; neurodevelopment; children

[1] Ahlborg, U. G., Brouwer, A., Fingerhut, M. A., Jacobson, J. L., Jacobson, S. W., Kennedy, S. W., Kettrup, A. A., Koeman, J. H., Poiger, H., Rappe, C. & et al. 1992. ”Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept.”Eur J Pharmacol, 228, 179-99.


[2] ATSDR 2005. Public Health Assessment Guidance Manual (Update).


[3] Gladen, B. C., Rogan, W. J., Hardy, P., Thullen, J., Tingelstad, J. & Tully, M. 1988. ”Development after exposure to polychlorinated biphenyls and dichlorodiphenyl dichloroethene transplacentally and through human milk.”The Journal of Pediatrics, 113, 991-995.


[4] Hui, L. L., Lam, H. S., Lau, E. Y. Y., Nelson, E. A. S., Wong, T. W. & Fielding, R. 2016. ”Prenatal dioxin exposure and neurocognitive development in Hong Kong 11-year-old children.”Environmental Research, 150, 205-212.


[5] Jacobson, J. L. & Jacobson, S. W. 1996. ”Intellectual impairment in children exposed to polychlorinated biphenyls in utero.”N Engl J Med, 335, 783-9.


[6] Kono, Y., Oka, A., Tada, H., Itabashi, K., Matsui, E. & Nakamura, Y. 2015. ”Perinatal dioxin exposure and psychosocial and behavioral development in school-aged children.”Early Hum Dev, 91, 499-503.


[7] Koopman-Esseboom, C., Weisglas-Kuperus, N. 1996. ”Effects of Polychlorinated Biphenyl/Dioxin Exposure and Feeding Type on Infants’ Mental and Psychomotor Development.”Pediatrics.


[8] Lai, T.-J., Guo, Y.-L., Yu, M.-L., Ko, H.-C. & Hsu, C.-C. 1994. ”Cognitive development in Yucheng children.”Chemosphere, 29, 2405-2411.


[9] Lynch, C. D., Jackson, L. W., Kostyniak, P. J., McGuinness, B. M. & Buck Louis, G. M. 2012. ”The effect of prenatal and postnatal exposure to polychlorinated biphenyls and child neurodevelopment at age twenty-four months.”Reproductive Toxicology, 34, 451-456.


[10] Malisch, R. & Kotz, A. 2014. ”Dioxins and PCBs in feed and food — Review from the European perspective.”The science of The Total Environment, 491–492, 2-10.


[11] Milbrath, M. O. G., Wenger, Y., Chang, C.-W., Emond, C., Garabrant, D., Gillespie, B. W. & Jolliet, O. 2009. ”Apparent Half-Lives of Dioxins, Furans, and Polychlorinated Biphenyls as a Function of Age, Body Fat, Smoking Status, and BreastFeeding.”Environmental Health Perspectives, 117, 417-425.


[12] Mitoma, C., Uchi, H., Tsukimori, K., Yamada, H., Akahane, M., Imamura, T., Utani, A. & Furue, M. 2015. ”Yusho and its latest findings—A review in studies conducted by the Yusho Group.”Environment International, 82, 41-48.


[13] Moher, D., Liberati, A., Tetzlaff, J. & Altman, D. G. 2009. ”Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement.”Annals of Internal Medicine, 151, 264-269.


[14] Nakajima, S., Saijo, Y., Kato, S., Sasaki, S., Uno, A., Kanagami, N., Hirakawa, H., Hori, T., Tobiishi, K., Todaka, T., Nakamura, Y., Yanagiya, S., Sengoku, Y., Iida, T., Sata, F. & Kishi, R. 2006. ”Effects of prenatal exposure to polychlorinated biphenyls and dioxins on mental and motor development in Japanese children at six months of
age.”Environmental Health Perspectives, 116.


[15] Nakamura, T., Nakai, K., Matsumura, T., Suzuki, S., Saito, Y. & Satoh, H. 2008. ”Determination of dioxins and polychlorinated biphenyls in breast milk, maternal blood and cord blood from residents of Tohoku, Japan.”A science of The Total Environment, 394, 39-51.


[16] Needham, L. L. & Sexton, K. 2000. ”Assessing children’s exposure to hazardous environmental chemicals: an overview of selected research challenges and complexities.”J Expo Anal Environ Epidemiol, 10, 611-29.


[17] Neugebauer, J., Wittsiepe, J., Kasper-Sonnenberg, M., Schöneck, N., Schölmerich, A. & Wilhelma, M. 2015. ”The influence of low-level pre- and perinatal exposure to PCDD/Fs, PCBs, and lead on attention performance and attention-related behavior among German school-aged children: Results from the Duisburg Birth Cohort
Study.”International Journal of Hygiene and Environmental Health, 218.


[18] Nghi, T. N., Nishijo, M., Manh, H. D., Tai, P. T., Van Luong, H., Anh, T. H., Thao, P. N., Trung, N. V., Waseda, T., Nakagawa, H., Kido, T. & Nishijo, H. 2015. ”Dioxins and non ortho PCBs in breast milk of Vietnamese mothers living in the largest hot spot of dioxin contamination.”Environmental Science and Technology, 49, 5732-5742.


[19] Nishijo, M., Pham, T. T., Nguyen, A. T., Tran, N. N., Nakagawa, H., Hoang, L. V., Tran, A. H., Morikawa, Y., Ho, M. D., Kido, T., Nguyen, M. N., Nguyen, H. M. & Nishijo, H. 2014. ”2,3,7,8-Tetrachlorodibenzo-p-dioxin in breast milk increases autistic traits of 3-year-old children in Vietnam.”Mol Psychiatry, 19, 1220-6.


[20] Nishijo, M., Tai, P. T., Nakagawa, H., Maruzeni, S., Anh, N. T., Luong, H. V., Anh, T. H., Honda, R., Morikawa, Y., Kido, T. & Nishijo, H. 2012. ”Impact of Perinatal Dioxin Exposure on Infant Growth: A Cross-Sectional and Longitudinal Studies in DioxinContaminated Areas in Vietnam.”PLoS One, 7.


[21] Patandin, S., Lanting, C. I., Mulder, P. G. H., Boersma, E. R., Sauer, P. J. J. & WeisglasKuperus, N. 1999. ”Effects of environmental exposure to polychlorinated biphenyls and dioxins on cognitive abilities in Dutch children at 42 months of age.”The Journal of Pediatrics, 134, 33-41.


[22] Pemberthy, D., Quintero, A., Martrat, M. G., Parera, J., Ábalos, M., Abad, E. & Villa, A. L. 2016. ”Polychlorinated dibenzo-p-dioxins, dibenzofurans and dioxin-like PCBs in commercialized food products from Colombia.”The science of The Total Environment, 568, 1185-1191.


[23] Pham, T., Nishijo, M., Nguyen, A., Tran, N., Hoang, L., Tran, A., Nguyen, T. & Nishijo, H. 2015. ”Perinatal dioxin exposure and the neurodevelopment of Vietnamese toddlers at one year of age.”The science of the Total Environment, 536.


[24] Poland, A. & Knutson, J. 1982. ”2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity.”Annual Review of Pharmacology and Toxicology, 22, 517-554.


[25] Rogan, W. J. & Gladen, B. C. 1991. ”PCBs, DDE, and child development at 18 and 24 months.”Annals of Epidemiology, 1, 407-413.


[26] Skene SA, D. I., Greenberg M. 1989. ”Polychlorinated dibenzo-dioxins and polychlorinated dibenzofurans: the risks to human health.”Hum Toxicol.


[27] Suzuki, G., Nakano, M. & Nakano, S. 2005. ”Distribution of PCDDs/PCDFs and CoPCBs in human maternal blood, cord blood, placenta, milk, and adipose tissue: dioxins showing high toxic equivalency factor accumulate in the placenta.”Biosci Biotechnol Biochem, 69, 1836-47.


[28] Tai, P. T., Nishijo, M., Anh, N. T. N., Maruzeni, S., Nakagawa, H., Luong, H. V., Anh, T. H., Honda, R., Kido, T. & Nishijo, H. 2013. ”Dioxin exposure in breast milk and infant neurodevelopment in Vietnam.”Occupational and Environmental Medicine, 70, 656.


[29] Tai, P. T., Nishijo, M., Nghi, T. N., Nakagawa, H., Van Luong, H., Anh, T. H. & Nishijo, H. 2016. ”Effects of Perinatal Dioxin Exposure on Development of Children during the First 3 Years of Life.”The Journal of Pediatrics.


[30] Todaka, T., Hirakawa, H., Hori, T., Tobiishi, K., Iida, T.& Furue, M. 2007. ”Concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and non-ortho and mono-ortho polychlorinated biphenyls in the blood of Yusho patients.”Chemosphere, 66, 1983-1989.


[31] Tran, N., Pham, T., Ozawa, K., Nishijo, M., Nguyen, A., Tran, T., Hoang, L., Tran, A., Phan, V., Nakai, A., Nishino, Y. & Nishijo, H. 2016. ”Impacts of Perinatal Dioxin Exposure on Motor Coordination and Higher Cognitive Development in Vietnamese Preschool Children: A Five-Year Follow-Up.”Plos One.


[32] Ulaszewska, M. M., Zuccato, E. & Davoli, E. 2011. ”PCDD/Fs and dioxin-like PCBs in human milk and the estimation of infants’ daily intake: a review.”Chemosphere, 83, 774-82.


[33] UNEP 2001. Stockholm Convention on Persistent Organic Pollutants.


[34] Vreugdenhil, H. J. I., Lanting, C. I., Mulder, P. G. H., Boersma, E. R. & Weisglas-Kuperus, N. 2002. ”Effects of prenatal PCB and dioxin background exposure on cognitive and motor abilities in Dutch children at school age.”The Journal of Pediatrics, 140,48-56.


[35] Wilhelm, M., Wittsiepe, J., Lemm, F., Ranft, U., Krämer, U., Fürst, P., Röseler, S. C., Greshake, M., Imöhl, M., Eberwein, G., Rauchfuss, K., Kraft, M. & Winneke, G. 2008. ”The Duisburg birth cohort study: Influence of the prenatal exposure to PCDD/Fs and dioxin-like PCBs on thyroid hormone status in newborns and neurodevelopment of infants until the age of 24 months.”Mutation Research - Reviews in Mutation Research, 659, 83-92.