Published date: Nov 01 2018

Journal Title: KnE Life Sciences

Issue title: The Fifth International Luria Memorial Congress «Lurian Approach in International Psychological Science»

Pages: 481–494

DOI: 10.18502/kls.v4i8.3306

O Klochkovavgmu2012@bk.ru

V Gnezditsky

Evoked cognitive potentials are a promising experimental technique that can be useful in diagnosis of various cognitive disorders, especially connected to the various memory impairments. Of particular interest to researchers is the study of the cognitive evoked potentials’ latency when recognition of various stimuli is
involved. To study the physiological nature and functional role of evoked cognitive potentials observed during the reaction to stimuli, and to determine the degree of conscious control involved in this reaction, the experimental data were statistically analyzed to determine the numerical correlation between the working memory capacity and the cognitive potential’s latency. The cognitive EPs were measured for 166 healthy subjects and 63 others that had some pathological brain condition (discirculatory encephalopathy and other brain discirculatory disorders), varied by the age and gender. Measurements were done with the Neurosoft Neuro-MEP 4 computerized encephalography system, which implemented the standard method of large latency neural response measurement for P300 waves. Measurements were done in the setup where the subject had to recognize the significant stimuli and react to them by pressing a button. The significant stimulus was represented by a 2 kHz tone, while the insignificant stimuli were the frequently repeated 1 kHz tones.
The brainwaves were registered in Cz-M1 and Cz-M2 outputs. This method allowed detection and latency measurements of the main response components N2, P3a P3ab and N3. Working memory capacity was determined by the number of words from a 10–15 word sets correctly reproduced shortly after exposures, as outlined by Luria. A statistically significant nonlinear correlation was observed between the memory capacity and the EP’s latency, which was fitted by a modified hyperbolic function. Additionally, greater latencies were observed for subjects suffering from the memory disorders, and much shorter latencies were in general noted for the male subjects as opposed to the female ones. One more interesting observation was that in many
cases the absolute reaction time was less than the cognitive potential peak taken as a conscious decision, suggesting that it is in many cases an automatic reaction. Cognitive potentials measurements, being an instrumental method, allow a clinical psychologist much greater flexibility in his diagnostic repertory, as it can be used even in the cases where word tests cannot. Also, the reaction times shorter than the latency of conscious reaction to stimuli adds weight to the simultaneous codes theory of automatic reactions.

Keywords: working memory capacity (WMC), regression line, nonlinear correlation, test less WMC estimates, cognitive processes, working memory, cognitive evoked potentials simultaneous codes, positional game, conscious cognitive comparison, P300

[1] Buddley, A., Isaac, M., and Anderson, M. (2011). Pamyat [translated from English, ed. Reznikova, T. N.]. Saint-Petersburg: Piter.


[2] Gnezditsky, V. V., Charskaya, A. V., Korepina, O. S., et al. (2016). Otsenka obyoma operativnoy pamyati po dannym endogennykh vyzvannykh potentsialov metoda P300 [Estimates of working memory capacity based on endogenous evoked potentials by P300 method]. Annaly klinicheskoy nevrologii [Annas of Clinical Neurology], vol. 10, no. 1, pp. 27–34.


[3] Gnezditsky, V. V. and Korepina, O. S. (2011). Atlas po vyzvannym potentsialam mozga (prakticheskoye rukovodstvo, osnovannoye na analise konkretnykh klinicheskikh nablyudeniy) [Brain’s Evoked Potentials Handbook (A Practical Handbook Based on Clinical Observations)]. Ivanovo: PresSto.


[4] Gnezditsky, V. V., Revenok, E. V., Korepina, O. S., et al. (2001). P300 i neiropsikhologicheskiy profil pri kognitivnykh narusheniyakh i dementsii sosudistogo geneza [P300 and neuropsychological profile for cognitive disorders and vascular dementia]. Fiziologiya cheloveka [Human Physiology], vol. 27, no. 3, pp. 42–53.


[5] Zakharov, V. V. (2015). Umerennye kornitivnye narusheniya kak multidistsiplinarnaya problema [Moderate cognitive disorders as a multidisciplinary problem]. Zhurnal neirologii, neiropatofiziologii i psikhosomatiki [Journal of Neurology, Neuropatophysiology and Psychosomatics], vol. 2, pp. 5–10.


[6] Klochkova, O. I. (2014). Kolichestvennaya otsenka ispolzovaniya kratkovremennogo episodicheskogo bufera rabochey pamyati studentov pri vzaimodeistvii s kompyuterom [Numerical estimate of working memory short-time episodic buffer usagefor students interacting with a computer]. Tikhookeanskiy Meditsinskiy Zhurnal
[Pacific Journal of Medicine], vol. 3, pp. 93–96.


[7] Klochkova, O. I., Shabanov, G. A., Rybchenko, A. A., et al. (2016). Proyavlenie inertsionnosti raboty mozga po spektralnoy funktsii vyzvannoy rlektromagnitnoy aktivnosti [Signs of the brain inertia in spectral function of evoked electromagnetic activity]. Tikhookeanskiy Meditsinskiy Zhurnal [Pacific Journal of Medicine], vol. 4, pp.
26–30.


[8] Kropotov, Yu. D. (2010). Kolichestvennaya EEG, kognitivnye VP mozga cheloveka I neiroterapiya [Numerical EEG, Cognitive EPs of Human Brain and Neurotherapy]. Donetsk: Zaslavsky.


[9] Luria, A. R. (2008). Vysshie korkovye funktsii cheloveka [Higher Cortex Functions in Humans]. Saint-Petersburg: Piter.


[10] Naatanen, N. (1998). Vnimaniye i funktsii mozga [Attention and Brain Functions,translated from English, ed. Sokolov, E. N.]. Moscow: MGU Press.


[11] Popova, L. T. (1972). Pamyat i ee narusheniya ori ochagovukh porazheniyakh mozga [Memory and Its Disorders Due to Localized Brain Damage]. Moscow: Medicine.


[12] Revenok, E. V. (1999). Neirofiziologicheskiy profil i vyzvannye potentially u bolnykh s sosudistoy dementsiey korkovogo i podkorkovogo tipa [Neurophysiological profile and evoked potentials in the patients with the vascular dementia of cortical and subcortical types]. Ph.D thesis. Moscow: Self-published.


[13] Revenok, E. V., Grezditsky, V. V., and Korepina, O. S. (2001). Vyzvannye potentsialy v otsenke stareniya i dementsii [Evoked potentials in the estimates of aging and dementia], in V. V. Gnezditsky and A. M. Shamshinova (eds.) Opyt primeneniya vyzvannyakh potentsialov v klinicheskoy praktike [An Attempt of Application of
Invoked Potential in Clinical Practice]. Moscow: Antidor.


[14] Shvyrkov, V. B. (1995). Vvedenie v obyektivnuyu psikhologiyu. Neironalnye osnovy psikhiki [Introduction to the Objective Psychology. Neuronal Basis of the Mind]. Moscow: RAS Psychology Institute.


[15] Bennys, K., Portet, F., Touchon, J., et al. (2007). Diagnostic value of event-related evoked potentials N200 and P300 subcomponents in early diagnosis of Alzheimer’s disease and mild cognitive impairment. Journal of Clinical Neurophysiology, vol. 24, no. 5, pp. 405–412.


[16] Bledowski, C., Cohen Kadosh, K., Wibral, M., et al. (2006). Mental chronometry of working memory retrieval: A combined functional magnetic resonance imaging and event-related potentials approach. Journal of Neuroscience, vol. 26, no. 3, pp. 821– 829.


[17] Brazdil, M. and Dobsik, M. (2005). Combined event-related fMRI and intracerebral ERP study of evidence. Neuroimage, vol. 20, no. 2, pp. 1270–1282.


[18] Donchin, E., and Coles, M. G. H. (1988). Is the P300 component a manifestation of context updating? Behav. Electroencephalography and Clinical Neurophysiology, vol. 65, no. 5, pp. 344–360.


[19] Fabiani, M., Karis, D., and Donchin, E. (1986). E. P300 and recall in an incidental memory paradigm. Psychophysiology, vol. 23, no. 3, pp. 298–308.


[20] Fjell, A. M., Walhovd, K. B., Fischl, B., et al. (2007). Cognitive function, P3a/ P3b brain potentials, and cortical thickness in aging. Human Brain Mapping, vol. 28, no. 11, pp. 1098–1116.


[21] Goodin, D. S. and Martin, S. (1992). P300, cognitive capability, and personality: A correlational study of university undergraduates. Personality and Individual Differences, vol. 13, no. 5, pp. 533–543.


[22] Goodin, D. S. and Aminoff, M. J. (1986). Electrophysiological differences between subtypes of dementia. Brain, vol. 109, pp. 1103–1113.


[23] Grut, M., Jorm, A. F., Fratiglioni, L., et al. (1993). Memory complaints of elderly people in a population survey: variation according to dementia stage and depression. Journal of the American Geriatrics Society, vol. 41, no. 12, pp. 1295–1300.


[24] Juckel, G., Clotz, F., Frodl, T., et al. (2008). Diagnostic usefulness of cognitive auditory event-related P300 subcomponents in patients with Alzheimer’s disease. Journal of Clinical Neurophysiology, vol. 25, no. 3, pp. 147–152.


[25] Kok, A. (2001). On the utility of P3 amplitude as a measure of processing capacity. Psychophysiology, vol. 38, no. 3, pp. 557–577.


[26] Kugler, C. F., Taghavy, A., and Platt, D. (1993). The event-related P300 potential. Analyses of cognitive human brain aging: A review. Journal of Gerontology, vol. 39, pp. 280–303.


[27] Linden, D. E. J. (2005). The P300: Where in the brain is it produced and what does it tell us? Neuroscientist, vol. 11, pp. 563–576.


[28] McCarthy, G. and Donchin, E. (1981). A metric for thought: A comparison of P300 latency and reaction time. Science, vol. 211, pp. 77–80.


[29] Miller, G. F. (1956). The magical number seven, plus or minus two, some limits on our capacity for processing information. Psychological Review, vol. 63, pp. 81–83.


[30] Mulert, C. and Lemieux, L. (eds.) (2010). EEG and fMRI. Physiological Basis, Technique and Application. Berlin: Springer.


[31] Näätänen, R., Paavilainen, P., Rinne, T., et al. (2007). The mismatch negativity (MMN) in basic research of central auditory processing: A review. Clinical Neurophysiology, vol. 118, pp. 2544–2590.


[32] Pfefferbaum, A., Ford, J. M., and Johnson, R. (1984). Clinical application of P300. Electroencephalography and Clinical Neurophysiology, vol. 59, pp. 85–116.