KnE Life Sciences
ISSN: 2413-0877
The latest conference proceedings on life sciences, medicine and pharmacology.
Evaluation of Benzene Exposure and S-PMA as a Biomarker of Exposure to Workers in the Informal Footwear Industry
Published date: Jun 19 2018
Journal Title: KnE Life Sciences
Issue title: International Conference of Occupational Health and Safety (ICOHS 2017)
Pages: 496–507
Authors:
Abstract:
Benzene (C6H6) is one of the most widely used chemical compounds in the world. Although its use has been limited, humans may be exposed to benzene in the natural and industrial environments. Small-scale footwear industry still uses adhesives containing benzene. The benzene profile has been well-documented, and it has been classified as a carcinogen compound. The purpose of this study is to assess the risk of benzene exposure in the work environment and individual exposure in footwear factory in Ciomas, Bogor, West Java, during August–September 2017. Urine test with S-Phenylmercapturic Acid biomarker was performed on 40 workers and measurements performed simultaneously at 9 air sample points from 3 workshop locations in accordance with NIOSH 1501 method, risk-level assessment through calculation Risk Quotient (RQ) and Excess Cancer Risk (ECR). The S-PMA subject has not exceeded the exposure limit (>25 μg/g) as Biological Exposure Indices (BEIs) with a median value of 0.190 mg/g (min 0.019–max 17.61). The results of the air sample analysis showed 8 sampling points below the TLV (Threshold limit values) of 0.5 ppm (1.6 μg/m3) and 1 point of air sampling has exceeded 0.5 ppm (1.6 μg/m3) of 2, 1074 ppm. the result of calculation of minimum cancer risk, it has been obtained that 13 workers (32.5%) have cancer risk that has exceeded the reference value (ECR>1 ⋅10−4) and 27 (67.5%) have ECR < 1•10−4. In the calculation of real-time non-cancer risk, it has been obtained that 8 (20%) workers have had non-cancer risk (RQ>1) and 32 (80%) have RQ<1. The concentration of air and S-PMA of workers is still below the TLV, but considering the risk of cancer and non-cancer workers who have exceeded the reference value, it is necessary to improve the working conditions.
Keywords: benzene, S-PMA, risk assessment
References:
[1] Panggabean CA. Hubungan Pajanan Uap Pelarut Organik dengan Terjadinya Konjungtivitas dan Keluhan Iritasi Mata. 2006.
[2] IARC. Benzene. IARC Monograph 100F. 2012;1987:249–85. http:// monographs.iarc.fr/ENG/Monographs/vol100F/mono100F-24.pdf
[3] WHO. International Program On Chemical Safety, Environmental Health Criteria 150?: Benzene. 1993. http://www.inchem.org/documents/ehc/ehc/ehc150.htm
[4] US EPA. Toxicological Review of Benzene. Rev Lit Arts Am [Internet]. 2002;39(110):759–86. Available from: http://www.ncbi.nlm.nih.gov/pubmed/ 22050403
[5] NIOSH. National Standard for Manual Handling. 1990;1001, 2005(February 1990). https://www.safeworkaustralia.gov.au/system/files/documents/1702/ manualhandling_standardnohsc1001_1990.pdf
[6] ATSDR. Benzene Toxicity. 2006; https://www.atsdr.cdc.gov/hec/csem/benzene/ docs/benzene.pdf
[7] ATSDR. Toxicological Profile for Benzene. 2007 [cited 2017 Apr 2]; Available from: https://www.atsdr.cdc.gov/toxprofiles/tp3.pdf
[8] Lemeshow S, Hosmer Jr DW, Klar J, Lwanga SK. Part 1: Statistical Methods for Sample Size Determination. Adequacy Sample Size Heal Studi 1997;247. Available from: http://apps.who.int/iris/bitstream/10665/41607/1/0471925179_eng.pdf?ua=1.
[9] NIOSH. Hydrocarbons Aromatic. NIOSH Man Anal Methods (NMAM), Fourth Ed. 2003;127(3):1–7. https://www.cdc.gov/niosh/docs/2003-154/pdfs/1501.pdf.
[10] Louvar dan Louvar BD. Health and Environmental Risk Analysis: Fundamentals with Applications By Joseph Louvar and B. Diane Louvar Prentice Hall. 1998. 1998;1998.
[11] Manuela C, Gianfranco T, Maria F, Tiziana C, Carlotta C, Giorgia A, et al. Chemosphere Assessment of occupational exposure to benzene, toluene and xylenes in urban and rural female workers. Chemosphere [Internet]. 2012;87(7):813–9. Available from: http://dx.doi.org/10.1016/j.chemosphere.2012.01.008
[12] Fenga C. Occupational exposure and risk of breast cancer (Review). 2016;282–92. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774377/
[13] Habeebullah TM. Risk assessment of exposure to BTEX in the Holy City of Makkah. 2015;1155–62. https://link.springer.com/article/10.1007%2Fs12517-013-1231-8
[14] Lim S et al. Risk Assessment of Volatile Organic Compounds Benzene, Toluene, Ethylbenzene, and Xylene (BTEX) in Consumer Products. J Toxicol Environ Heal Part A [Internet]. 2014;77(22–24):1502–21. Available from: http://dx.doi.org/10.1080/ 15287394.2014.955905
[15] Mark A, D’Andrea, MD, Facro; Reddy KG. Illness Symptoms Experienced by Children Exposed to Benzene After a Flaring Incident at the BP Refinery Facility in Texas City. 2016; DOI: 10.5055/ajdm.2013.0124
[16] Azari MR et all. Evaluation of Occupational Exposure of Shoe Makers to Benzene and Toluene Compounds in Shoe Manufacturing Workshops in East Tehran. 2012;11(4):43–9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153221/
[17] Hanway R, Cavicchioli A, Kaur B, Parsons J, Lamb JH, Buckberry LD, et al. Analysis of S-phenyl-L-cysteine in globin as a marker of benzene exposure. Biomarkers. 2000;5(4):252–62. https://www.ncbi.nlm.nih.gov/pubmed/23885978
[18] Farmer PB, Kaur B, Roach J, Levy L, Consonni D, Bertazzi PA, et al. The use of S-phenylmercapturic acid as a biomarker in molecular epidemiology studies of benzene. Chem Biol Interact. 2005;153–154:97–102. https://www.ncbi.nlm.nih.gov/ pubmed/15935804
[19] Bi-hua Lv M, Shi-zhen Song P, Zhibing Zhang P, Yong Mei P, Fang-li Ye M. Urinary S-phenylmercapturic Acid as a Key Biomarker for Measuring Occupational Exposure to Low Concentrations of Benzene in Chinese Workers. J Occup Environ Med. 2014;56(3):319–25. https://www.ncbi.nlm.nih.gov/pubmed/24561506
[20] Boogaard PJ, Sittert NJ Van. Acid and of S-Phenyl Mercapturic Suitability for Acid as Biomarkers of Benzene to Low Concentrations Exposure. Environ Heal. 2009;104(December). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1469762/
[21] Chanvaivit S, Navasumrit P, Hunsonti P, Autrup H, Ruchirawat M. Exposure assessment of benzene in Thai workers, DNA-repair capacity and influence of genetic polymorphisms. Sci Direct. 2007;626:79–87. https: //www.ncbi.nlm.nih.gov/pubmed/17095285