Published date: May 17 2018

Journal Title: KnE Life Sciences

Issue title: The 2nd International Meeting of Public Health 2016 (IMOPH) – Part I

Pages: 384–390

DOI: 10.18502/kls.v4i4.2298

A Tahta Kurniawandoni@ui.ac.id

Z Prima Rizky

D Hikmat Ramdhan

Exposure to fine particles can cause chronic and acute inflammation that may change cells to be abnormal. Inflammation occurs when the human body responds to exposure to particulate matter (PM) by releasing Tumor Necrosis Factor-Alpha (TNF-α), a protein that signals inflammation. The object of the present study was to analyze the correlation between human exposure to PM and blood concentrations of TNF-α in Pusat Pengujian Kendaraan Bermotor (PKB), in Ujung Menteng and Pulogadung, in East Jakarta, Indonesia. The study included 42mechanics from PKB and 27 control participants. The independent T-test was used to assess the smoking status, obesity incidence, and age of the participants. In addition, TNF-α concentrations were
analyzed using a quantitative sandwich enzyme immune assay (ELISA) technique and a Human TNF-α/TNFSFIA HS. The study used quantitative analysis to compare TNF-α concentration with the variables in both sample groups. Results showed a higher average concentration of TNF-α inthe blood samples of the mechanics group
than in those of the control group (p-value < 0.05), meaning that PM2.5 exposure may increase TNF-α concentration in human blood.

Keywords: Particulate Matter 2.5 (PM2.5), Tumor Necrosis Factor-Alpha (TNF-α),
Inflammation

[1] Brook, RD. Cardiovascular Effects of Air Pollution. Clin Sci. 2008;115(6):175–187


[2] Cheng, Y. H., Chang, H-P., & Yan, J-W. (2012). Temporal Variation in Airborne Particulate Matter Levels at an Indoor Bus Terminal and Exposure Implications for Terminal Workers. Aerosol and Air Quality Research, 12, 30–38


[3] Csiszar, A., Ungyari, Z., Edward, J. G., Kaminski, P. M., Wollin, M. S., Koller, A., & Kaley, G. (2002). Aging - Induced Phenotypic Changes and Oxidative Stress Impair Coronary Arteriolar Function. Circulation, 90, 1159 1166


[4] Ding, Ding YS, Zhang L, Jain RB, Jain N, Wang RY, Ashley DL, Watson CH. 2008. Levels of Tobacco Specific Nitrosamines and Polycyclic Aromatic Hydrocarbons in Mainstream Smoke from Different Tobacco Varieties. Cancer Epidemiological Biomarker, 3366–3371


[5] Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM.1995. Weight Reducing Effects of the Plasma Protein Encoded by the Obese Gene. Science, 269(5223):543-6


[6] Horiuchi T, Mitoma H, Harashima S , Tsukamoto H, and Shimoda T (2010). Transmembrane TNF-a Structure, Function, and Interaction with anti-TNF agents. Rheumatology, 49(7), 1215–1228


[7] Indriyani, A. (2016). Gambaran Konsentrasi Pajanan personal particulate matter 2.5 (PM 2.5) dan Keluhan Pernapasan Subyektif pada Petugas Uji Mekanis di Pusat Pengujian Kendaraan Bermotor (PKB) Ujung Menteng Tahun 2015. Universitas Indonesia

[8] Kafoury, M. R., & Madden, M. C. (2004). Diesel Exhaust Particles Induce the Over Expression of Tumor Necrosis Factor a (TNF-α) Gene in Alveolar Macrophages and Failed Induced Apoptosis Through Activation of Nuclear Factor-