Published date: Sep 20 2015

Journal Title: KnE Life Sciences

Issue title: International Conference on Biological Sciences (ICBS-2013)

Pages: 422-426

DOI: 10.18502/kls.v2i1.186

Rr. Upiek Ngesti Wibawaning Astutiupiekastuti@ugm.ac.idFaculty of Biology Universitas Gadjah Mada

Imam FathoniFaculty of Biology Universitas Gadjah Mada

Tanti RahayuFaculty of Biology Universitas Gadjah Mada

Ahmad Rizki PrasetyoFaculty of Biology Universitas Gadjah Mada

Bioactivities evaluation of mahoni’s seed ethanolic extract on the parasitemic level of Plasmodium berghei have conducted in Parasitology laboratory Universitas Gadjah Mada. Peter’s four days test (1970) was used in this research. There were 27 of mice and randomly was devided into 9 groups, 3 mice of each groups. There were 4 groups of controls: control with extract only, control with P. berghei infection only, control with P. berghei infection and chloroquin, and placebo. The other 5 groups of treated mice were mice treated with extract at the dose 5,75; 12.5; 25; 50; and100 mg/kg of body weight. Results showed that saponin and terpenoid were detected as bioactive compound. Mahoni’s seed extract at the dose 50 mg/kg of body weight gave the good effectivness in reducing the parasite up to 60% compare with control + chloroquin.

Keywords: Plasmodium berghei, Swietenia mahagoni, parasitemic level, mice

Anonim. 2008. Indonesia masih menjadi negara endemis tinggi malaria. http: // www.pdpersi.co.id. Accessed: 20 Desember 2009.
CDC. 2012. Malaria. http://www.cdc.gov/malaria/ .Accessed 29 April 2012
Goulart, H.R., E.A. Kimura, V.J. Peres, A.S. Couto, F.A.A. Duarte, and A.M. Katzin. 2004. Terpenes arrest parasite development and inhibit biosynthesis of isoprenoids Plasmodium falciparum. Amer. Soc. For Micro. 48 (7): 2505-2509.
Harianja.2008.Mahoni dan Pemanfaataannya. http://www.bpdas pemalijratun.net/ index.php?option=com_content&view=article&id=61:mahoni &catid=18:tanaman­berkayu&Itemid=31. Accessed: 29 April 2012
Harborne, J.B. 1987. Phytochemical Methods: A Guide to Modern Techniques of Plant Analysis. Chapman & Hall Inc. London,
Herbert, R.B. 1995. Biosintesis metabolit sekunder. Trnaslated by: Bambang Srigandono. Semarang: IKIP Semarang Press.
Janse, C., and A. Waters. 2007. The Plasmodium berghei research model of malaria. www.lumc.nl/1040/research/malaria.model05.html . Accessed: : 29 April 2012
Levine, N.D. 1995. Protozoologi veteriner. Yogyakarta: Gadjah Mada University Press.
Nogueira, C. R., and L. M. X. Lopes. 2011. Antiplasmodial Natural Products. Molecules. 16: 2146-2190.
Peter, Y. 1970. Technique for study of drug response in experimental malaria chemotherapy and drug resistance in malaria. New York: Academic Press.
Saxena, S., N. Pant, D.C. Jain, and R.S. Bhakuni. 2003. Antimalarial Agents from Plant Sources. Curr. Sc. 85 (9): 1314-1329.
Su, V., D. King, I. Woodrow, G. McFadden, and R. Gleadow. 2008. Plasmodium falciparum growth is arrested by monoterpenes from eucalyptus oil. Flav. And Frag. Jou. (23): 315­318.
Widodo, G.P., dan M. P. Rahayu. 2010. Aktivitas Antimalaria Ekstrak Etil Asetat Kulit Batang Mundu (Garcinia dulcis Kurz). Maj. Farm. Indo. 2 (4): 238 – 242