KnE Life Sciences

ISSN: 2413-0877

The latest conference proceedings on life sciences, medicine and pharmacology.

Oxidative Stability of Nano-Encapsulated Candlenut Oil

Published date: Dec 27 2022

Journal Title: KnE Life Sciences

Issue title: Science and Technology Research Symposium (SIRES)

Pages: 282–289

DOI: 10.18502/kls.v7i5.12537

Authors:

A. F. Hidayataulia.fikri.h@unisba.ac.idDepartment of Pharmacy, Universitas Islam Bandung, Jalan Ranggagading No. 8, Bandung, Indonesia

R. AryaniDepartment of Pharmacy, Universitas Islam Bandung, Jalan Ranggagading No. 8, Bandung, Indonesia

R. ChoesrinaDepartment of Pharmacy, Universitas Islam Bandung, Jalan Ranggagading No. 8, Bandung, Indonesia

I. D. NovitaDepartment of Pharmacy, Universitas Islam Bandung, Jalan Ranggagading No. 8, Bandung, Indonesia

A. M. DeviDepartment of Pharmacy, Universitas Islam Bandung, Jalan Ranggagading No. 8, Bandung, Indonesia

Abstract:

Candlenut has a lot of potential pharmacological benefits including in hair care, in treating skin problems such as psoriasis, and in its use as an emollient. However, the high unsaturated fatty acid content of candlenut oil causes it to be easily degraded by oxidation due to exposure to air, light, and humidity. Nanoencapsulations were found to be an alternative in protecting the materials from degradation. The purpose of this study was to investigate the effect of polymer-based nanoencapsulations on the oxidative stability of candlenut oil. Polyvinyl alcohol (PVA) was used as a polymer wall material. A lower peroxide value indicates better oil stability against oxidation. Results showed that nano-encapsulated candlenut oil has a significantly lower average peroxide value of 0.41 meq/100g over 35 days storage time, compared to 3.8 meq/100g in pure candlenut oil. Furthermore, based on its physical characterization, it was found that the reduction of particle size with the optimal size of 172±12 nm was achieved by increasing the amount of PVA. A well-chosen and well-calculated amount of polymer material, therefore, plays an important role to obtain optimal nano-encapsulated candlenut oil.

Keywords: nanoencapsulation, candlenut oil, oxidative stability, polymeric materials

References:

[1] Klean AP, Beach ES, Emerson JW, Zimmerman JB. J Agric Food Chem. 2010;58:10045–8.

[2] Siddique BM, Ahmad A, Alkarkhi AF, Ibrahim MH, K MO. Chemical composition and antioxidant properties of candlenut oil extracted by supercritical CO2. J Food Sci. 2011 May;76(4):C535–42.

[3] Muhammud A, Abu Bakar R, Amin AR, Jaafar R. The effectiveness of coconut oil mixed with herbs to promote hair growth. International Journal of Ethics in Engineering &. Manage Educ. 2014;1(3):27–30.

[4] Brown AC, Koett J, Johnson DW, Semaskvich NM, Holck P, Lally D, et al. Effectiveness of kukui nut oil as a topical treatment for psoriasis. Int J Dermatol. 2005 Aug;44(8):684–7.

[5] Athar M, Nasir SM. Afr J Biotechnol. 2005;4(1):36–44.

[6] Ako H, Kong N, Brown A. Fatty acid profiles of kukui nut oils over time and from different sources. Ind Crops Prod. 2005;22(2):169–74.

[7] LaMer VK. Retardation of Evaporation by Monolayers: Transport Processes. In: LaMer VK, editor. Retardation of Evaporation by Monolayers: Transport Processes. New York: Academic Press; 1962.

[8] Grubauer G, Elias PM, Feingold KR. Transepidermal water loss: the signal for recovery of barrier structure and function. J Lipid Res. 1989 Mar;30(3):323–33.

[9] Matalanis A, Decker EA, McClements DJ. Inhibition of lipid oxidation by encapsulation of emulsion droplets within hydrogel microspheres. Food Chem. 2012;132(2):766–72.

[10] M.L. Martínez, M.I. Curti, P. Roccia, et al., “Oxidative stability of walnut ( Juglans regia L.) and chia (Salvia hispanica L.) oils microencapsulated by spray drying.,” Powder Technology. vol. 270, pp. 271–277, 2015

[11] C. de Campo, P.P. Dos Santos, T.M.H. Costa, et al., “Nanoencapsulation of chia seed oil with chia mucilage (Salvia hispanica L.) as wall material: Characterization and stability evaluation.,” Food chemistry. vol. 234, no. 11, pp. 1–9, 2017

[12] Waraho T, Mcclements DJ, Decker EA. Mechanisms of lipid oxidation in food dispersions. Trends Food Sci Technol. 2011;22(1):3–13.

[13] Ephrem E, Greige-Gerges H, Fessi H, Charcosset C. Optimisation of rosemary oil encapsulation in polycaprolactone and scale-up of the process. J Microencapsul. 2014;31(8):746–53.

[14] C. Pinto Reis, R.J. Neufeld, A.J. Ribeiro, and F. Veiga, “Nanoencapsulation I. Methods for preparation of drug-loaded polymeric nanoparticles.,” Nanomedicine: Nanotechnology, Biology and Medicine. vol. 2, no. 1, pp. 8–21, 2006

[15] Guterres SS, Alves MP, Pohlmann AR. Polymeric nanoparticles, nanospheres and nanocapsules, for cutaneous applications. Drug Target Insights. 2007;2:147–57.

[16] Vahidmoghadam F, Pourahmad R, Mortazavi A, Davoodi D, Azizinezhad R. Characteristics of freeze-dried nanoencapsulated fish oil with whey protein concentrate and gum arabic as wall materials. Food Sci Technol (Campinas). 2019;39 suppl 2:475–81.

[17] Rigo LA, da Silva CR, de Oliveira SM, Cabreira TN, de Bona da Silva C, Ferreira J, et al. Nanoencapsulation of rice bran oil increases its protective effects against UVB radiation-induced skin injury in mice. Eur J Pharm Biopharm. 2015 Jun;93:11–7.

[18] Singh H, Kumar C, Singh N, Paul S, Jain SK. Nanoencapsulation of docosahexaenoic acid (DHA) using a combination of food grade polymeric wall materials and its application for improvement in bioavailability and oxidative stability. Food Funct. 2018 Apr;9(4):2213–27.

[19] Ruiz Ruiz JC, Ortiz Vazquez EL, Segura Campos MR. Encapsulation of vegetable oils as source of omega-3 fatty acids for enriched functional foods. Crit Rev Food Sci Nutr. 2017 May;57(7):1423–34.

[20] Salaün F, Bedek G, Devaux E, Dupont D, Gengembre L. Microencapsulation of a cooling agent by interfacial polymerization: influence of the parameters of encapsulation on poly(urethane–urea) microparticles characteristics. J Membr Sci. 2011;370(1-2):23–33.

[21] Romanski FS, Jayjock E, Muzzio FJ, Tomassone MS. Important Factors in the Size Reduction of Polymer-Stabilized Drug Particle Suspensions Using High-Pressure Homogenization. J Pharm Innov. 2011;6(2):97–106.

[22] J. M. A. Alsharef, M.R. Taha, and T. Ahmed Khan, “PHYSICAL DISPERSION OF NANOCARBONS IN COMPOSITES–A REVIEW.,” Jurnal Teknologi. vol. 79, no. 5, pp. 69–81, 2017

[23] Park JS, Lee HJ, Choi SJ, Geckeler KE, Cho J, Moon SH. Fouling mitigation of anion exchange membrane by zeta potential control. J Colloid Interface Sci. 2003 Mar;259(2):293–300.

Download
HTML
Cite
Share
statistics

302 Abstract Views

213 PDF Downloads