KnE Life Sciences

ISSN: 2413-0877

The latest conference proceedings on life sciences, medicine and pharmacology.

In-Silico Investigation of Beta-Cyclodextrin as a Stabilizer for Pineapple Peel Extract Mediated Silver Nanoparticles

Published date: Dec 27 2022

Journal Title: KnE Life Sciences

Issue title: Science and Technology Research Symposium (SIRES)

Pages: 254–262

DOI: 10.18502/kls.v7i5.12534

Authors:

H. A. WisnuwardhaniEmail: hilda.aprilia@gmail.com
Affiliation: Department of Pharmacy, Faculty of Mathematic and Sciences, Universitas Islam Bandung, Bandung, Indonesia
Biography:

Y. LukmayaniEmail: N/A
Affiliation: Department of Pharmacy, Faculty of Mathematic and Sciences, Universitas Islam Bandung, Bandung, Indonesia
Biography:

K. M. YuliawatiEmail: N/A
Affiliation: Department of Pharmacy, Faculty of Mathematic and Sciences, Universitas Islam Bandung, Bandung, Indonesia
Biography:

Y. PermanasariEmail: N/A
Affiliation: Department of Pharmacy, Faculty of Mathematic and Sciences, Universitas Islam Bandung, Bandung, Indonesia
Biography:

H. A. Wisnuwardhani - hilda.aprilia@gmail.com

Y. Lukmayani

K. M. Yuliawati

Y. Permanasari

Abstract:

Pineapple peel waste was used in this study as a source of ferulic acid that has antioxidant and antibacterial properties. Pineapple peel extract can be used as a bioreductor in the synthesis of silver nanoparticles (AgNPs). Beta cyclodextrins are often added as stabilizers in the synthesis of AgNPs to increase their stability. This study aimed to investigate through in silico study the efficacy of beta cyclodextrin as a stabilizer in the synthesis of AgNPs. It also investigated whether ferulic acid plays the role of a bioreductor in the stabilization mechanism of the AgNPs. Molecular docking simulation was used to investigate the efficacy of beta cyclodextrin as a stabilizer in AgNPs synthesis using MGLTools 1.5.6 with AutodockTools 4.2. The visualization of each complex was observed using BIOVIA Discovery Studio Visualizer 2020. The results of this study showed that beta cyclodextrin had better affinity by stabilizing six AgNPs atoms, which was indicated by a free binding energy value of -5.15 kJ/mol. The presence of ferulic acid in the extract which was used as a bioreductor in the synthesis of AgNPs also had a better affinity for the six AgNPs atoms which was indicated by free binding energy of -2.51 kJ/mol. It can be concluded that beta cyclodextrins play the role of being a stabilizer in AgNPs synthesis.

Keywords: in silico, beta-cyclodextrin, silver nanoparticles

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