KnE Life Sciences

ISSN: 2413-0877

The latest conference proceedings on life sciences, medicine and pharmacology.

The Effect of Aqueous Extract of Robusta Coffee Compared to Neomycin-Bacitracin on Wound Healing by Measuring TNF-1 and bFGF in Fibroblast Cell Cultures

Published date: Dec 27 2022

Journal Title: KnE Life Sciences

Issue title: Science and Technology Research Symposium (SIRES)

Pages: 129–139

DOI: 10.18502/kls.v7i5.12519

Authors:

H. S. YuwonoEmail: hsyabc47@gmail.com
Affiliation: Postgraduate Program, Faculty of Medicine, Universitas Islam Bandung, Bandung, Indonesia
Biography:

M. PutriEmail: N/A
Affiliation: Department of Biochemistry, Nutrition and Biomolecular, Faculty of Medicine, Universitas Islam Bandung, Bandung, Indonesia
Biography:

W. PurbaningsihEmail: N/A
Affiliation: Department of Histology, Faculty of Medicine, Universitas Islam Bandung, Bandung, Indonesia
Biography:

N. M. MarsyaEmail: N/A
Affiliation: Undergraduate Program, Faculty of Medicine, Universitas Islam Bandung, Bandung, Indonesia
Biography:

S. A. SumantriEmail: N/A
Affiliation: Undergraduate Program, Faculty of Medicine, Universitas Islam Bandung, Bandung, Indonesia
Biography:

H. S. Yuwono - hsyabc47@gmail.com

M. Putri

W. Purbaningsih

N. M. Marsya

S. A. Sumantri

Abstract:

Coffee grounds have been used to dress wounds for more than 100 years, with excellent results. The wound heals with an acceptable scar. This study aims to compare coffee extract to neomycin-bacitracin in cell migration. Compared to the antibiotic neomycin-bacitracin powder group and control group in scar tissue formation, the Robusta coffee powder extract measured positively on Transforming Growth Factor and Basic Fibroblast Growth Factor markers. This study emphasizes the ability of coffee to heal wounds without causing excessive scarring. Coffee is proven to have better wound healing capabilities than Neomycin-Bacitracin.

Keywords: coffee grounds, fibroblast cell-line, Transforming Growth Factor, basic Fibroblast Growth Factor

References:

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[2] Yuwono HS. Kopi untuk mengobati luka. Bandung: PT. Refika Aditama; 2013

[3] Gilbert RW, Vickaryous MK, Viloria-Petit AM. Signalling by Transforming Growth Factor Beta Isoforms in Wound Healing and Tissue Regeneration. J Dev Biol. 2016;4(2):1–21.

[4] Wang P, Shu B, Xu Y, Zhu J, Liu J, Zhou Z, et al. Basic fibroblast growth factor reduces scar by inhibiting the differentiation of epidermal stem cells to myofibroblasts via the Notch1/Jagged1 pathway. Stem Cell Res Ther. 2017 May;8(1):114.

[5] Shi HX, Lin C, Lin BB, Wang ZG, Zhang HY, Wu FZ, et al. The anti-scar effects of basic fibroblast growth factor on the wound repair in vitro and in vivo. PLoS One. 2013;8(4):e59966.

[6] Seo HY, Jung YA, Lee SH, Hwang JS, Park KG, Kim MK, et al. Kahweol decreases hepatic fibrosis by inhibiting the expression of connective tissue growth factor via the transforming growth factor-beta signaling pathway. Oncotarget. 2017 Aug;8(50):87086–94.

[7] Akita S, Akino K, Hirano A. Basic Fibroblast Growth Factor in Scarless Wound Healing. Adv Wound Care. 2013 Mar;2(2):44–9.

[8] Wang L, Ko CY, Meyers EE, Pedroja BS, Pelaez N, Bernstein AM. Concentrationdependent effects of transforming growth factor β1 on corneal wound healing. Mol Vis. 2011;17:2835–46.

[9] Yuwono HS. American Journal of Medical Case Reports. 2019;7(5):94–6.

[10] Garna H, Yuwono HS, Tejasari M. Vulnerable Wound-base Cells Protected by Coffee Powder to Better Healing. American Journal of Medical Case Reports. 2019;7(9):214– 6.

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