Published date: Dec 03 2017

Journal Title: KnE Life Sciences

Issue title: The Veterinary Medicine International Conference (VMIC)

Pages: 460-467

DOI: 10.18502/kls.v3i6.1155

Neni AnggraeniGraduate School of Biomedical Sciences Master Program, Faculty of Medicine Universitas Padjajaran, Bandung Medical Laboratorium Technologyst of Bakti Asih School of Analyst, Bandung

Mas Rizky A.A SyamsunarnoDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Padjadjaran, Bandung Central Laboratory, Universitas Padjadjaran, Bandung Biotechnology Study Program, Post graduate School, Universitas Padjadjaran, Bandung

Ghina Rahmadianti MukarromahDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Padjadjaran, Bandung

Almira ZadaDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Padjadjaran, Bandung

Rima Destya TriatinDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Padjadjaran, Bandung

Yunisa PamelaDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Padjadjaran, Bandung

Diah DhianawatyDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Padjadjaran, Bandung

Imperata cylindrica L. extract was studied for its effect on cholesterol absorption rate in mice (Mus muscularis). Male mice (20-25g) were divided control and pre-treated group. Pretreated group was further divided into two groups that received different dose of Imperata cylindrica L. extract gavage (90mg/KgBW and 115mg/KgBW) for 2 weeks. Mice were fasted 12 hour before acutely given olive oil gavage with dosage of 10 µl/g, and blood was collected at 0, 2, and 6 hour-time points on the indicated day. Blood was collected from the retroorbital plexus at indicated time points. Total cholesterol level was significantly (p<0.05) decreased in both pretreated groups at 6 hours after acute olive oil gavage. In conclusion, there is a significant effect of Imperata cylindrica L. extract to reduce cholesterol level in serum, suggesting its potential effect as an antihypercholesterolemia therapy.

Key words: Imperata cylindrical L.; cholesterol absorption; antihypercholesterolemia; lipid absorption; herbal medicine

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