KnE Life Sciences
ISSN: 2413-0877
The latest conference proceedings on life sciences, medicine and pharmacology.
Iron Overload Reduces Cholestrol and Triglyceride Serum of Mice
Published date: Dec 03 2017
Journal Title: KnE Life Sciences
Issue title: The Veterinary Medicine International Conference (VMIC)
Pages: 369-377
Authors:
Abstract:
Most of the case of patient with hemoglobin disorder genes need routine blood transfusion throughout their life. It leads to increase iron accumulation with liver as the main organ for iron storage. Liver is the main organ for metabolic process, including triglyceride and cholesterol. However, correlation between metabolism of triglyceride and cholesterol, and iron overload condition is remain uncertain. The purpose of this study was to investigate the effect of iron overload to triglyceride and cholesterol level in the serum of mice.
Keywords: iron overload; Triglyceride serum; Cholesterol Serum.
References:
1. Organization WHO. Sickle-cell disease and other haemoglobin disorders. Sickle-cell disease and other haemoglobin disorders2006.
2. Porter JB, Shah FT. Iron overload in thalassemia and related conditions: therapeutic goals and assessment of response to chelation therapies. Hematology/oncology clinics of North America. 2010;24(6):1109-30.
3. Merono T, Gomez L, Sorroche P, Boero L, Arbelbide J, Brites F. High risk of cardiovascular disease in iron overload patients. European journal of clinical investigation. 2011;41(5):479-86.
4. Kaplan J, Ward DM, De Domenico I. The molecular basis of iron overload disorders and iron-linked anemias. International journal of hematology. 2011;93(1):14-20.
5. Munoz M, Garcia-Erce JA, Remacha AF. Disorders of iron metabolism. Part II: iron deficiency and iron overload. Journal of clinical pathology. 2011;64(4):287-96.
6. Marsella M, Borgna-Pignatti C. Transfusional iron overload and iron chelation therapy in thalassemia major and sickle cell disease. Hematology/oncology clinics of North America. 2014;28(4):703-27, vi.
7. Oudit GY, Sun H, Trivieri MG, Koch SE, Dawood F, Ackerley C, et al. L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy. Nature medicine. 2003;9(9):1187-94.
8. Shander A, Sazama K. Clinical consequences of iron overload from chronic red blood cell transfusions, its diagnosis, and its management by chelation therapy. Transfusion. 2010;50(5):1144-55.
9. Ahmed U, Latham PS, Oates PS. Interactions between hepatic iron and lipid metabolism with possible relevance to steatohepatitis.
World journal of gastroenterology. 2012;18(34):4651-8.
10. Anderson ER, Shah YM. Iron homeostasis in the liver. Comprehensive Physiology. 2013;3(1):315-30.
11. Munoz M, Garcia-Erce JA, Remacha AF. Disorders of iron metabolism. Part 1: molecular basis of iron homoeostasis. Journal of clinical pathology. 2011;64(4):281-6.
12. Sebastiani G, Pantopoulos K. Disorders associated with systemic or local iron overload: from pathophysiology to clinical practice. Metallomics : integrated biometal science. 2011;3(10):971-86.
13. Nelson JE, Wilson L, Brunt EM, Yeh MM, Kleiner DE, Unalp-Arida A, et al. Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease. Hepatology. 2011;53(2):448-57.
14. Graham RM, Chua AC, Carter KW, Delima RD, Johnstone D, Herbison CE, et al. Hepatic iron loading in mice increases cholesterol biosynthesis. Hepatology. 2010;52(2):462-71.
15. Syamsunarno MR, Iso T, Hanaoka H, Yamaguchi A, Obokata M, Koitabashi N, Goto K, Hishiki T, Nagahata Y, Matsui H, Sano M. A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting. PLoS One. 2013 Nov 14;8(11):e79386.
16. Fernández-Real JM, Manco M. Effects of iron overload on chronic metabolic diseases. The Lancet Diabetes & Endocrinology. 2014 Jun 30;2(6):513-26.
17. Jiri Petrak DM, Petr Man, Radek Cmejla, Jana Cmejlova, Milan Elleder, ChristoperD Vulpe. Proteomic analysis of hepatic iron overload in mice suggests dysregulation of urea cycle, impairment of fatty acid oxidation, and changes in the methylation cycle. American journal of physiology Gastrointestinal and liver physiology. 2007;292:490-8.
18. Anggraeni N, Syamsunarno M, Triatin RD, Setiawati DA, Rakhimullah AB, Irianti C, et al. Iron overload intolerance in Balb/c mice. Advances in Biomolecular Medicine: CRC Press/Balkema; 2017. p. 1-4.
19. Choi JS, Koh IU, Lee HJ, Kim WH, Song J. Effects of excess dietary iron and fat on glucose and lipid metabolism. The Journal of nutritional biochemistry. 2013 Sep 30;24(9):1634-44