Published date: Dec 03 2017

Journal Title: KnE Life Sciences

Issue title: The Veterinary Medicine International Conference (VMIC)

Pages: 139-152

DOI: 10.18502/kls.v3i6.1123

Maslichah MafruchatiStudent Airlangga University Faculty of Medicine, Airlangga University

Mas’ud HarijadiDepartment of Reproduction Veterinary Science Airlangga University Faculty of Medicine, Airlangga University

Widjiati WidjiatiDepartment of Anatomy Veterinary Anatomy Airlangga University Faculty of Medicine, Airlangga University

Boerhan HidayatDirector of Specific Infection Hospital Airlangga University Faculty of Medicine, Airlangga University

Birth defect (congenital defect / congenital condition) is an anomaly appearing at birth and able to cause the physical or mental defect or death. Birth defect generally can be detected during the prenatal period. However, if this cannot be detected during the prenatal period, it can be identified at the post natal examination. Congenital Bilateral Absence Vas Difference (CBAVD) is of one the congenital defects characterized by Azoospermia causing the occurrence of infertility. This congenital defect can bring impact to the structural, functional and metabolism anomalies. Approximately 7.9 million children in the world (about 6% of the whole anomalies in the world) were born with serious congenital defects every year due to genetic anomaly or other post-conception. The determination of optimal output from PCR optimization to obtain the location of ∆F 508-T mutant on CBAVD patients in Indonesia is conducted pursuant to the gene target. The conclution were influence of various factors as the indicator specifying the mutation of ∆F 508-T mutant needs to be considered in making a decision for the preliminary research on CBAVD in Indonesia.

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