Published date: Oct 08 2018

Journal Title: KnE Engineering

Issue title: Breakthrough directions of scientific research at MEPhI: Development prospects within the Strategic Academic Units

Pages: 216–223

DOI: 10.18502/keg.v3i6.2996

K A Prosolovkonstprosolov@gmail.com

A Sainova

A Osite

Yu P Sharkeev

K A Gross

Strontium substituted hydroxyapatite is a biomaterial with high level of biocompatibility with improved cell proliferation from Sr ions in hydroxyapatite. The aim of this research is to study the effect of saturated steam pressure at elevated temperature on the transitions within amorphous strontium hydroxyapatite powder. Processing temperatures and times ranged from 90 to 150∘C for periods of 1, 3 and 6 hours, respectively. Powder was characterized by X-Ray Diffraction and Fourier Transformed Infrared Spectroscopy. The appearance of diffraction peaks in the X-ray diffraction pattern suggested that longer processing times were necessary to transform amorphous strontium hydroxyapatite to a higher crystallinity at lower temperatures. Transition from the amorphous to the crystalline state begins at 150∘C after an hour, at 120∘C after 3 hours, or at 110∘C after 6 hours. Infrared spectroscopy showed the characteristic phosphate absorption band and the presence of carbonate in the powder.

Keywords: hydrothermal processing, biomaterials, hydroxyapatite, material design, biocompatibility

[1] Dorozhkin, S. V. and Epple, M. (2002). Biological and medical significance of calcium phosphates. Angewandte Chemie - International Edition, vol. 41, no. 17. pp. 3130– 3146.


[2] Rangavittal, N., Landa-Cánovas, A. R., González-Calbet, J. M., et al. (2000). Structural study and stability of hydroxyapatite and beta-tricalcium phosphate: Two important bioceramics. Journal of Biomedical Materials Research, vol. 51, no. 4, pp. 660–668.


[3] Yu, H., Zhang, H., Wang, X., et al. (2007). Local structure of hydroxy-peroxy apatite: A combined XRD, FT-IR, Raman, SEM, and solid-state NMR study. Journal of Physics and Chemistry of Solids, vol. 68, no. 10, pp. 1863–1871.


[4] Abd El-Fattah, H., Helmy, Y., El-Kholy, B., et al. (2010). In vivo animal histomorphometric study for evaluating biocompatibility and osteointegration of nanohydroxyapatite as biomaterials in tissue engineering. Journal of the Egyptian National Cancer Institute, vol. 22, no. 4, pp. 241–250.


[5] Noda, I., Miyaji, F., Ando, Y., et al. (2010). Next generation antibacterial hydroxyapatite coating: antibacterial activity of ag ions in serum. Bioceramics Development and Applications, vol. 1, pp. 1–3.


[6] Terra, J., Dourado, E. R., Eon, J.-G., et al. (2009). The structure of strontiumdoped hydroxyapatite: An experimental and theoretical study. Physical Chemistry Chemical Physics, vol. 11, no. 3, pp. 568–577.


[7] Grynpas, M. D., Hamilton, E., Cheung, R., et al. (1996). Strontium increases vertebral bone volume in rats at a low dose that does not induce detectable mineralization defect. Bone, vol. 18, no. 3, pp. 253–259.


[8] P. J. Marie, P. Ammann, G. Boivin, and C. Rey, “Mechanisms of action and therapeutic potential of strontium in bone,” Calcified Tissue International, vol. 69, no. 3. pp. 121– 129, 2001.


[9] Dahl, S. G., Allain, P., Marie, P. J., et al. (2001). Incorporation and distribution of strontium in bone. Bone, vol. 28, no. 4, pp. 446–453.


[10] Gopi, D., Nithiya, S., Kavitha, L., et al. (2012). Amino acid-assisted synthesis of strontium hydroxyapatite bone cement by a soft solution freezing method. Bulletin of Materials Science, vol. 35, no. 7, pp. 1195–1199.


[11] Sakai, A., Valanezahad, A., Ozaki, M., et al. (2012). Preparation of Sr-containing carbonate apatite as a bone substitute and its properties. Dental Materials Journal, vol. 31, no. 2, pp. 197–205.


[12] Yang, C. W. and Lui, T. S. (2009). Kinetics of hydrothermal crystallization under saturated steam pressure and the self-healing effect by nanocrystallite for hydroxyapatite coatings. Acta Biomaterialia, vol. 5, no. 7, pp. 2728–2737.


[13] Meguro, K. and Ikeya, M. (1992). Stabilization of radicals by doping from aqueous solutions into crystals of hydroxyapatite. Japanese Journal of Applied Physics, vol. 31, no. 5, p. 1353.


[14] Zhao, H., Li, X., Wang, J., et al. (2000). Characterization of peroxide ions in hydroxyapatite lattice. Journal of Biomedical Materials Research, vol. 52, no. 1, pp. 157–163.


[15] Gross, K. A., Komarovska, L., and Viksna, A. (2013). Efficient zinc incorporation in hydroxyapatite through crystallization of an amorphous phase could extend the properties of zinc apatites. Journal of the Australian Ceramic Society, vol. 49, no. 2, pp. 129–135.


[16] Kavitha, M., Subramanian, R., Vinoth, K. S., et al. (2015). Optimization of process parameters for solution combustion synthesis of Strontium substituted Hydroxyapatite nanocrystals using Design of Experiments approach. Powder Technology, vol. 271, pp. 167–181.


[17] Regnier, P., Lasaga, A. C., Berner, R. A., et al. (1994). Mechanism of CO3- substitution in carbonate-fluorapatite: Evidence from FTIR spectroscopy, 13C NMR, and quantum mechanical calculations. American Mineralogist, vol. 79, pp. 809–818.