Published date: Oct 08 2018

Journal Title: KnE Engineering

Issue title: Breakthrough directions of scientific research at MEPhI: Development prospects within the Strategic Academic Units

Pages: 196–201

DOI: 10.18502/keg.v3i6.2992

N A Lipeynikolayalexlipey@gmail.com

K G Linkov

D V Yakovlev

V V Volkov

V B Loschenov

The aim of the study is to optimize the irradiation procedure during endobiliary photodynamic therapy for patients with cholangiocarcinoma. The studies were performed using fiber-optic light delivery tools in various configurations and using different irradiation power levels. Control of photosensitizer accumulation at the site of therapy was also applied. It is shown that the use of fiber-optic light delivery tools with cylindrical diffusers provides more effective and less painful photodynamic therapy. It is shown that after the injection of the photosensitizer, there is an optimal time for the therapy, when the maximum difference in the accumulation of the photosensitizer in the tumor is observed in comparison with the intact tissue.

Keywords: endobiliary photodynamic therapy, fluorescent diagnostics, fiber-optic light delivery tools, cholangiocarcinoma

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