KnE Energy

ISSN: 2413-5453

The latest conference proceedings on energy science, applications and resources

Fine-tuning of Silica Coating Procedure for Preparation of Biocompatible and Bright Pbs/Sio2 Qds

Published date:Apr 17 2018

Journal Title: KnE Energy

Issue title: The 2nd International Symposium "Physics, Engineering and Technologies for Biomedicine"

Pages:578–582

DOI: 10.18502/ken.v3i2.1868

Authors:
Abstract:

Near-infrared semiconductor PbS quantum dots (QDs) with emission in biological transparency window are promising material for in vivo biolabelling and deep-tissue imaging of biological specimen. Among various approaches that render initially hydrophobic and toxic QDs biocompatible, the growth of a silica shell on the QD surface represents an efficient method to minimize QD toxicity. Nevertheless, it is important to preserve QDs emission properties after the silica coating procedure. Here we report on the optimal parameters of this procedure which allow to obtain a stable silica shell and maintain the optical properties of initial PbS QDs. Furthermore, we show that PbS QDs with the optimal SiO2 shell retain their luminescence quantum yield even after condensation into a solid film. Thus, our procedure can become a basis in development of bright, receptor-targeted NIR fluorescent probes for in vivo tumor imaging.

Keywords: quantum dot, SiO2 shell, bioimaging

References:

[1] R. Bilan, I. Nabiev, A. Sukhanova, “Quantum dot-based nanotools for bioimaging, diagnostics, and drug delivery,” ChemBioChem, vol. 17, pp. 2103–2114, 2016.


[2] G. Rousserie, A. Sukhanova, K. Even-Desrumeaux, et al.,”Semiconductor quantum dots for multiplexed bio-detection on solid-state microarrays,” Crit. Rev. Oncol. Hematol., vol. 74, pp. 1-15, 2010.


[3] Y. Du, P. Yang. K. Matras-Postolek, et al.,”Low toxic and highly luminescent CdSe/Cd

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