Published date:Apr 17 2018

Journal Title: KnE Energy

Issue title: The 2nd International Symposium "Physics, Engineering and Technologies for Biomedicine"

Pages:513–518

DOI: 10.18502/ken.v3i2.1859

V K Tishchenko

V M Petrievpetriev@mrrc.obninsk.ru

A A Mikhailovskaya

O A Smoryzanova

Amino acids are important nutrients for proliferating tumor cells, so their transport is generally increased in many malignant tumor cells. Radiolabeled amino acids are of great interest as they can be alternative or complement tracers to the already wellestablished radiopharmaceuticals such as 18F-FDG. The purpose of this study was to synthesize and characterize a novel 68Ga labeled leucine analog, 68Ga-leucine, as a potential imaging agent for tumors which may not be amenable to imaging by 18F-FDG PET. Biodistribution studies of 68Ga-leucine were performed in Wistar rats with transplanted cholangioma RS-1 xenografts after intravenous injection. 68Ga-leucine demonstrated high in vivo stability. Accumulation of 68Ga-leucine at xenograft tumors was about 2-4 higher as compared with 68GaCl3 and reached 0.79% ID/g. Among the soft tissue organs, only kidney had a relatively high uptake. The amount of radioactivity in other organs didn’t exceed 1% ID/g. The results suggest that 68Ga-leucine has the potential to be a new additional diagnostic tool for PET imaging of tumors.

Keywords: gallium-68, leucine, radiolabeled amino acids, positron emission tomography, tumor imaging.

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