Published date:Apr 17 2018

Journal Title: KnE Energy

Issue title: The 2nd International Symposium "Physics, Engineering and Technologies for Biomedicine"

Pages:476–485

DOI: 10.18502/ken.v3i2.1854

S V Stepanovstepanov@itep.ru

L Yu Dubov

Yu A Akmalova

V M Byakov

Yu V Shtotsky

A V Bokov

Chemical carcinogens are the main cause of cancer. Many thousands of new chemicals are synthesized annually in the world, unknown part of them is carcinogens. There are several methods, which are currently used for testing carcinogenicity. The fastest arephysicochemical methods. We suggest the method of fast carcinogen screening using the positron annihilation spectroscopy (PAS). It is based on the fact that the presence of carcinogens, being strong electrophiles, significantly decreases positronium (Ps) formation probability. This quantity can be measured by means of conventional PAS techniques: positron annihilation lifetime spectroscopy (PALS), angular correlation of annihilation radiation (ACAR) or Doppler broadening of annihilation radiation (DBAR). It is also possible to evaluate anti-carcinogenic properties of chemicals using the anti-inhibition effect of Ps formation.

Keywords: carcinogen, electrophilicity, positron annihilation spectroscopy, positronium

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