Published date:Apr 17 2018

Journal Title: KnE Energy

Issue title: The 2nd International Symposium "Physics, Engineering and Technologies for Biomedicine"

Pages:278–282

DOI: 10.18502/ken.v3i2.1822

V N Morozovmorozov.v.n@mail.ru

A V Belousov

G A Krusanov

M A Kolyvanova

A P Chernyaev

A A Shtil

Gold nanoparticles attract attention for the use in radiation therapy of tumors due to the ability to enhance the efficacy of ionizing radiation. The magnitude of the radiosensitizing effect depends on the parameters of the nanoparticle, in particular on the modification of the surface. In the present work, the spectrum of secondary particles generated in a gold nanoparticle virtually irradiated with 60Со gamma rays as a result of surface modification by a polyethylene glycol shell was studied. The Mont eCarlo calculations revealed that modification of the nanoparticle’s surface changes the spectrum of secondary particles. The most robust was the loss in low-energy electrons (51%) whereas the yield of Compton electrons increased by 1.27 times. At the same time, no statistically significant changes were observed in the spectrum of secondary photons and photoelectrons. Simulation of the formation and distribution of secondary electron radiation makes it possible to evaluate the parameters important for the rational design of antitumor nanoradiosensitizers based on chemical elements with a high atomic number.

Keywords: gold nanoparticles, radiosensitizers, Monte-Carlo simulation, Geant4, radiation therapy, malignant tumors.

[1] J.F. Hainfeld, D.N. Slatkin, and H.M. Smilowitz, “The use of gold nanoparticles to enhance radiotherapy in mice,” Physics in Medicine & Biology, vol. 49, no. 18, pp.309-315, 2004.


[2] M. Gilles, E. Brun, and C. Sicard-Roselli, “Gold nanoparticles functionalization notably decreases radiosensitization through hydroxyl radical production under ionizing radiation,” Colloids and Surfaces B: Biointerfaces, vol. 123, pp. 770-777, 2014.


[3] C. Spaas, R. Dok, O. Deschaume, B. De Roo, M. Vervaele, J.W. Seo, C. Bartic, P. Hoet, F. Van den Heuvel, S. Nuyts, J.P. Locquet, “Dependence of Gold Nanoparticle Radiosensitization on Functionalizing Layer Thickness,” Radiation Research, vol. 185, no. 4, pp. 384-392, 2016.


[4] B. Koger, and C. Kirkby, “Dosimetric effects of polyethylene glycol surface coatings on gold nanoparticle radiosensitization,” Physics in Medicine & Biology, vol. 62, pp. 8455-8469, 2017.


[5] V.V. Terekhin, I.N. Senchikhin, O.V. Dement’eva, and V.M. Rudoy, “Conjugates of gold nanoparticles and poly(ethylene glycol): Formation in hydrosol, direct transfer to organic medium, and stability of organosols,” Colloid Journal, vol. 7, no. 4, pp. 511- 519, 2015.