Published date: Apr 29 2021

Journal Title: Journal of Ophthalmic and Vision Research

Issue title: April–June 2021, Volume 16, Issue 2

Pages: 291 – 294

DOI: 10.18502/jovr.v16i2.9093

Narges HassanpoorRetina & Vitreous Service, Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran

Ahmad MirshahiRetina & Vitreous Service, Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran

Mohammad Reza Niyoushamreza63neusha@gmail.comRetina & Vitreous Service, Nikookari Eye Hospital, Tabriz University of Medical Sciences, Tabriz, Iran

Purpose: To present the second case of photopigment bleaching phenomenon in fluorescein angiography (FA) and the first case of this phenomenon due to impending central retinal vein occlusion (CRVO).

Case Report: A 32-year-old healthy female noticed blurred vision in her right eye one day before presentation. Despite the 20/20 visual acuity at presentation, mild increased retinal vascular tortuosity and unilateral photopigment bleaching phenomenon in FA was observed in the right eye. Three weeks later, she developed a complete CRVO with visual acuity reduction to 20/40 that responded well to the intravitreal injection of aflibercept.

Conclusion: Impending CRVO can cause unilateral photopigment bleaching phenomenon in FA that may be due to retinal ischemia.

Keywords: Autofluorescence, Central Retinal Vein Occlusion, Fluorescein Angiography, Photopigment Bleaching, Scanning Laser Ophthalmoscopy

1. Yung M, Klufas MA, Sarraf D. Clinical applications of fundus autofluorescence in retinal disease. Int J Retin Vitr 2016;2:12.

2. Breazzano MP, Fernandez-Avellaneda P, Kurup SK, Freund KB. Photopigment bleaching phenomenon with scanning laser ophthalmoscopy and fluorescein angiography. Ophthalmic Surg Lasers Imaging Retina 2019;50:590–592.

3. Choi KE, Yun C, Kim YH, Kim SW, Oh J, Huh K. The effect of photopigment bleaching on fundus autofluorescence in acute central serous chorioretinopathy. Retina 2017;37:568–577.

4. Joseph A, Rahimy E, Freund KB, Sorenson JA, Sarraf D. Fundus autofluorescence and photoreceptor bleaching in multiple evanescent white dot syndrome. Ophthalmic Surg Lasers Imaging Retina 2013;44:588–592.