Journal of Ophthalmic and Vision Research
ISSN: 2008-322X
The latest research in clinical ophthalmology and the science of vision.
Tapioca Melanoma of the Iris: a Case Report
Published date: Jul 18 2019
Journal Title: Journal of Ophthalmic and Vision Research
Issue title: July–September 2019, Volume 14, Issue 3
Pages: 376 – 381
Authors:
Abstract:
Purpose: To report an extremely rare case of tapioca melanoma of the iris in an Iranian patient.
Case Report: A 50-year-old male patient presented with ocular pain and redness in the right eye for two weeks. The visual acuity was 7/10 and the intraocular pressure (IOP) was 30 mmHg. A lobulated amelanotic vascularized and nodular (tapioca-like) iris mass with a 180o extent was seen in the right eye. Incisional biopsy of the mass revealed atypical mixed type (epithelioid and spindle cell) melanoma. Brachytherapy with the ruthenium-106 plaque resulted in complete regression of the tumor.
Conclusion: Tapioca melanoma of the iris should be considered in the differential diagnosis of patients presenting with nodular vascularized amelanotic iris mass and elevated IOP. Brachytherapy with ruthenium-106 seems to be an effective treatment for tapioca melanoma of the iris.
Keywords: Brachytherapy; Iris Melanoma; Tapioca Melanoma
References:
1. Pick ZS, Wilson GA. Tapioca melanoma of the iris. Clin Exp Optom 2009;922:154–156.
2. Iwamoto T, Reese AB, Mund ML. Tapioca melanoma of the iris. 2. Electron microscopy of the melanoma cells
compared with normal iris melanocytes. Am J Ophthalmol 1972;745:851–861.
3. Reese AB, Mund ML, Iwamoto T. Tapioca melanoma of the iris. 1. Clinical and light microscopy studies. Am J
Ophthalmol 1972;745:840–850.
4. Demirci H, Shields CL, Shields JA, Eagle RC, Jr, Honavar SG. Diffuse iris melanoma: A report of 25 cases. Ophthalmology 2002;1098:1553–1560.
5. de Keizer RJ, Oosterhuis JA, Houtman WA, de WolffRouendaal D. Tapioca melanoma of the iris. Ann Ophthalmol 1993;255:195–198.
6. Viestenz A, Conway RM, Kuchle M. Tapioca melanoma of the iris mimicking a vascular tumour: a clinicopathological correlation. Clin Exp Ophthalmol 2004;323:327–330.
7. Heegaard S, Jensen OA, Prause JU. Immunohistochemical diagnosis of malignant melanoma of the conjunctiva
and uvea: Comparison of the novel antibody against melan-A with S100 protein and HMB-45. Melanoma Res
2000;104:350–354.
8. Hassenstein A, Bialasiewicz AA, von Domarus D, Schafer H, Richard G. Tapioca melanomas of the iris: Immunohistology and report on two cases. Graefes Arch Clin Exp Ophthalmol 1999;2375:424–428.
9. Naumann G, Volcker HE. [Block-excision of intraocular processes. II. Epithelial ingrowth into the anterior segment of the eye (author’s transl)]. Klin Monbl Augenheilkd 1975;1664:448–457.
10. Zakka KA, Foos RY, Sulit H. Metastatic tapioca iris melanoma. Br J Ophthalmol 1979;6311:744–749.
11. Singh AD, Shields CL, Shields JA, Sato T. Uveal melanoma in young patients. Arch Ophthalmol 2000;1187:918–923.
12. Viestenz A, Berger T, Kuchle M. Cutaneous melanoma metastasizing to the iris and choroid: A case report.
Graefes Arch Clin Exp Ophthalmol 2002;24012:1036– 1038
13. Bach A,McGowan S, Gold AS, Villegas VM, Wildner AC, Ehlies FJ, et al. Tapioca melanoma of the iris without iris
heterochromia. Optom Vis Sci 2014;914:S20–S24
14. Razzaq L, Keunen JE, Schalij-Delfos NE, Creutzberg CL, Ketelaars M, de Keizer RJ. Ruthenium plaque radiation
therapy for iris and iridociliary melanomas. Acta Ophthalmol 2012;903:291–296.
15. Wilkinson DA, Kolar M, Fleming PA, Singh AD. Dosimetric comparison of 106Ru and 125I plaques for treatment of shallow (
16. Agraval U, Sobti M, Russell HC, Lockington D, Ritchie D, Cauchi P, et al. Use of Ruthenium-106 brachytherapy for iris melanoma: The Scottish experience. Br J Ophthalmol 2018;1021:74–78.