Published date: Apr 29 2022

Journal Title: Journal of Ophthalmic and Vision Research

Issue title: April–June 2022, Volume 17, Issue 2

Pages: 202 – 208

DOI: 10.18502/jovr.v17i2.10791

Monireh GhasempourDepartment of Neuroscience, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran

Masoud Khorrami-NejadDr.khorraminejad@gmail.comOptometry Department, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran

Aidin SafvatiSchool of Optometry and Vision Science, University of New South Wales, Sydney, Australia

Babak MasoomianTranslational Ophthalmology Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran

Purpose: To evaluate the effect of interocular axial length (AL) difference on outcomes of treatment for anisometropic amblyopia in comparison with normal participants.

Methods: In this historical cohort study, 83 patients with anisometropic amblyopia were divided into two age groups, 70 children (mean, 7.86 ± 1.56 and range, 5–15 years) and 13 adults (mean, 26.46 ± 10.87 and range, 16–45 years). The control group consisted of 43 non-amblyopic children and 17 non-amblyopic adults. Treatment outcomes after a period of one year were defined as successful or unsuccessful when posttreatment amblyopic corrected distance visual acuity (CDVA) was reported as ≤0.9 versus CDVA ≤ 0.8, respectively. AL was measured using a Lenstar LS900 (Haag-Streit AG, Switzerland).

Results: Fifty-nine patients showed satisfactory treatment outcomes (55 children and 4 adults), while unsuccessful treatment outcomes were observed in 24 patients (15 children and 9 adults). The mean of amblyopia treatment duration was 1.24 ± 0.76 years. The mean of interocular AL difference in all patients, control, successful and unsuccessful treatment outcome groups were 0.49 ± 0.70mm (range, 0.00–3.89 mm), 0.12 ± 0.07 mm (range, 0.02–0.41), 0.33 ± 0.23 mm (range, 0.00–0.99 mm), and 1.81 ± 0.80 mm (range, 1.14–3.89 mm), respectively. In both age groups, the mean of interocular AL difference in patients with unsuccessful treatment outcomes was greater than those with successful treatment outcomes and that of the control group (P < 0.001).

Conclusion: The results of this study suggest that the outcome of anisometropic amblyopia treatment may depend on the interocular AL difference.

Keywords: Anisometropic Amblyopia, Axial Length, Refractive Error

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