Journal of Ophthalmic and Vision Research
ISSN: 2008-322X
The latest research in clinical ophthalmology and the science of vision.
An Alternate Technique for Goniotomy: Description of Procedure and Preliminary Results
Published date: Apr 29 2022
Journal Title: Journal of Ophthalmic and Vision Research
Issue title: April–June 2022, Volume 17, Issue 2
Pages: 170 – 175
Authors:
Abstract:
Purpose: Multiple glaucoma treatment modalities seek to lower IOP by bypassing or removing a portion of the juxtacanalicular trabecular meshwork. These procedures often require expensive implants or specialized surgical instruments. The authors developed a technique for ab interno goniectomy utilizing a standard disposable 25-gauge hypodermic needle. The surgical procedure—termed bent ab interno needle goniectomy (BANG)—and preliminary results are presented here.
Methods: A retrospective chart review was performed for all patients who underwent goniotomy using a modified hypodermic needle by one of the three authors between July 2017 and June 2018. The mean and standard deviation pre- and postoperative IOP and the number of glaucoma medications were calculated. The student paired t-test was used to compare pre- and postoperative data. A P-value of <0.05 was considered statistically significant.
Results: At postoperative month six, the mean IOP was 13.3 ± 2.5 mmHg (P = 3.6 × 10−7) on 0.5 ± 0.8 topical glaucoma medications (P = 0.01). A ≥20% reduction in IOP was achieved in 73% of patients. Seventy-three percent of patients required ≥1 fewer medication, while 73% of patients required no medications for IOP control. Forty-one percent of those treated achieved IOP ≤12 mmHg.
Conclusion: The BANG procedure is a low-cost MIGS technique available to surgeons around the world with preliminary outcomes similar to more expensive alternatives.
Keywords: Glaucoma, Goniotomy, Microinvasive Glaucoma Surgery
References:
1. Tham YC, Li X, Wong TY, Quigley HA, Aung T, Cheng CY, et al. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology 2014;121:2081–2090.
2. Grant WM. Clinical measurements of aqueous outflow. AMA Arch Ophthalmol 1951;46:113–131.
3. Grant WM. Experimental aqueous perfusion in enucleated human eyes. Arch Ophthalmol 1963;69:783–801.
4. Tamm ER. The trabecular meshwork outflow pathways: structural and functional aspects. Exp Eye Res 2009;88:648–655.
5. Herschler J, Davis EB. Modified goniotomy for inflammatory glaucoma. Histologic evidence for the mechanism of pressure reduction. Arch Ophthalmol 1980;98:684–687.
6. Luntz MH, Livingston DG. Trabeculotomy ab externo and trabeculectomy in congenital and adult-onset glaucoma. Am J Ophthalmol 1977;83:174–179.
7. Anderson DR. Trabeculotomy compared to goniotomy for glaucoma in children. Ophthalmology 1983;90:805–806.
8. Jacobi PC, Dietlein TS, Krieglstein GK. Technique of goniocurettage: a potential treatment for advanced chronic open angle glaucoma. Br J Ophthalmol 1997;81:302–307.
9. Minckler DS, Baerveldt G, Alfaro MR, Francis BA. Clinical results with the Trabectome for treatment of open-angle glaucoma. Ophthalmology 2005;112:962–967.
10. Seibold LK, Soohoo JR, Ammar DA, Kahook MY. Preclinical investigation of ab interno trabeculectomy using a novel dual-blade device. Am J Ophthalmol 2013;155:524–529.
11. Grover DS, Godfrey DG, Smith O, Feuer WJ, Montes de Oca I, Fellman RL. Gonioscopy-assisted transluminal trabeculotomy, ab interno trabeculotomy: technique report and preliminary results. Ophthalmology 2014;121:855–861.
12. Samuelson TW1, Katz LJ, Wells JM, Duh YJ, Giamporcaro JE. Randomized evaluation of the trabecular micro-bypass stent with phacoemulsification in patients with glaucoma and cataract. Ophthalmology 2011;118:459–467.
13. Manasses DT, Au L. The new era of glaucoma micro-stent surgery. Ophthalmol Ther 2016;5:135–146.
14. Jea SY, Francis BA, Vakili G, Filippopoulos T, Rhee DJ. Ab interno trabeculectomy versus trabeculectomy for openangle glaucoma. Ophthalmology 2012;119:36–42.
15. Ting JL, Damji KF, Stiles MC. Ab interno trabeculectomy: outcomes in exfoliation versus primary open-angle glaucoma. J Cataract Refract Surg 2012;38:315–323.
16. Francis BA, See RF, Rao NA, Minckler DS, Baerveldt G. Ab interno trabeculectomy: development of a novel device (Trabectome) and surgery for open-angle glaucoma. J Glaucoma 2006;15:68–73.
17. Grover DS, Godfrey DG, Smith O, Shi W, Feuer WJ, Fellman RL. Outcomes of Gonioscopy-assisted Transluminal Trabeculotomy (GATT) in eyes with prior incisional glaucoma surgery. J Glaucoma 2017;26:41–45.
18. Wilmsmeyer S, Philippin H, Funk J. Excimerlaser trabeculotomy: a new, minimally invasive procedure for patients with glaucoma. Graefes Arch Clin Exp Ophthalmol 2006;244:670–676.
19. Neuhann TH, Scharrer A, Haefliger E. Excimer laser trabeculostomy (ELT) in the treatment of chronic open angle glaucoma. Ophthalmo-Chirurgies 2001;13:2–7.
20. Vogel M, Lauritzen K. Punktuelle excimerlaserablation des trabekelwerks. Ophthalmologe 1997;94:665–667.
21. Hodapp E, Heuer DK. A simple technique for goniotomy. Am J Ophthalmol 1986;102:537.
22. Laroche D, Okaka Y, Ng C. A novel low cost effective technique in using a 23 gauge straight cystotome to perform goniotomy: making Micro-invasive Glaucoma Surgery (MIGS) accessible to the Africans and the diaspora. J Natl Med Assoc 2019;111:193–197.
23. Dorairaj SK, Seibold LK, Radcliffe NM, Aref AA, Jimenez- Román J, Lazcano-Gomez GS, et al. 12-month outcomes of goniotomy performed using the Kahook Dual Blade combined with cataract surgery in eyes with medically treated glaucoma. Adv Ther 2018;35:1460–1469.